Association of IL-10, IL-4, and IL-28B Gene Polymorphisms with Spontaneous Clearance of Hepatitis C Virus in a Population from Rio De Janeiro

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2012 Sep 19

PMID 22986179

Citations 10

Authors

Juliene Antonio Ramos

Rosane Silva

Luisa Hoffmann

Ana Lucia Araujo Ramos

Pedro Hernan Cabello

Turan Peter Urmenyi

Cristiane Alves Villella-Nogueira

Lia Lewis-Ximenez

Edson Rondinelli

Affiliations

Soon will be listed here.

Abstract

Background: Cytokines play an important role in the regulation of the immune response. In hepatitis C virus (HCV) infection, cytokine levels may influence the outcome of acute HCV infection. Polymorphisms in cytokine genes have been associated to different expression levels in response to infection. This study was carried out to investigate the association of several cytokine gene polymorphisms with disease outcome in HCV-infected patients.

Findings: Patients with chronic or spontaneously resolved HCV infection were included in a cross-sectional study. A comparative analysis was performed between the groups regarding frequency distribution of the following cytokines' gene polymorphisms: IL-10 (-1082 A/G; -819 T/C; -592 A/C), IL-4 (+33C/T), IFN-γ (+874 T/A), TNF-α (-238 G/A and -308 G/A) and IL-28B (rs12979860 C/T and rs8099917 T/G).

Results: Eighteen patients with spontaneous viral clearance and 161 with chronic HCV infection were included. In the comparative analysis, the GG genotype of the IL-10 polymorphism -1082A/G was more frequent in patients with spontaneous viral clearance when compared to patients with chronic HCV (41.2% vs 6.2%; p = 0.001). This association was also found for the CC genotype of the IL-4 polymorphism +33C/T (72.2% vs 36.7%; p = 0.017) and the CC and TT genotypes of the IL-28B polymorphisms rs 12979860 and rs 8099917 (88.9% vs 30.3%; p < 0.001 and 88.9% vs 49.6%; p = 0.002). The IL10 (A-1082 G) and IL-28B (Crs12979860T) gene polymorphisms showed odds ratios of 12.848 and 11.077, respectively, and thus may have a greater influence on HCV spontaneous viral clearance. The IFN-γ (+874 T/A), TNF-α (-238 G/A and -308 G/A) polymorphisms did not show significant association with spontaneous viral clearance or chronicity.

Conclusion: The G allele for IL-10 (-1082 A/G), the C allele for IL-4 (+3 C/T) and the C and T alleles for IL-28B (rs12979860 and rs8099917, respectively) are associated with spontaneous viral clearance in hepatitis C infection.

Citing Articles

Role of Inflammatory/Immune Response and Cytokine Polymorphisms in the Severity of Chronic Hepatitis C (CHC) before and after Direct Acting Antiviral (DAAs) Treatment.

Ferreira J, Oliveira M, Bicho M, Serejo F Int J Mol Sci. 2023; 24(2).

PMID: 36674897 PMC: 9865726. DOI: 10.3390/ijms24021380.

TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection.

Santiago A, da Silva Graca Amoras E, Queiroz M, Conde S, Cayres-Vallinoto I, Ishak R BMC Infect Dis. 2021; 21(1):1133.

PMID: 34732154 PMC: 8567538. DOI: 10.1186/s12879-021-06835-9.

Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection.

Zhang J, Chen N, Chen Z, Liu Y, Zheng K, Qiu Y Front Immunol. 2020; 11:587669.

PMID: 33262767 PMC: 7686574. DOI: 10.3389/fimmu.2020.587669.

Interaction effects among IFN-γ+874, IL-2-330, IL-10-1082, IL-10-592 and IL-4-589 polymorphisms on the clinical progression of subjects infected with hepatitis B virus and/or hepatitis C virus: a retrospective nested case-control study.

Gao Q, Xie J, Wang L, Zhou Q, Zhang S BMJ Open. 2017; 7(8):e013279.

PMID: 28838891 PMC: 5577879. DOI: 10.1136/bmjopen-2016-013279.

Lack of association between interleukin 28B gene polymorphisms (rs8099917G/T, rs12979860 C/T) and susceptibility to chronic hepatitis C virus infection, Tehran, Iran.

Karkhane M, Mohebbi S, Azimzadeh P, Saeedi Niasar M, Sarbazi M, Sharifian A Gastroenterol Hepatol Bed Bench. 2017; 9(Suppl1):S29-S35.

PMID: 28224025 PMC: 5310797.

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