In Vitro Production of IFN-gamma Correlates with CA Repeat Polymorphism in the Human IFN-gamma Gene

Overview

Journal Eur J Immunogenet

Specialty Allergy & Immunology

Date 1999 Mar 9

PMID 10068907

Citations 96

Authors

V Pravica

A Asderakis

C Perrey

A Hajeer

P J Sinnott

I V Hutchinson

Affiliations

Soon will be listed here.

Abstract

The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.

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