An Investigation of Polymorphism in the Interleukin-10 Gene Promoter

Overview

Journal Eur J Immunogenet

Specialty Allergy & Immunology

Date 1997 Feb 1

PMID 9043871

Citations 415

Authors

D M Turner

D M Williams

D Sankaran

M Lazarus

P J Sinnott

I V Hutchinson

Affiliations

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Abstract

Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

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