James E Dowling
Overview
Explore the profile of James E Dowling including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
18
Citations
161
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Lemay S, Montesinos M, Grobs Y, Yokokawa T, Shimauchi T, Mougin M, et al.
Circulation
. 2025 Jan;
PMID: 39829438
Background: Pulmonary arterial hypertension (PAH) is characterized by obliterative vascular remodeling of the small pulmonary arteries (PAs) and progressive increase in pulmonary vascular resistance leading to right ventricular failure. Although...
2.
Harrison B, Dowling J, Bursavich M, Troast D, Chong K, Hahn K, et al.
J Med Chem
. 2024 Oct;
67(21):18656-18681.
PMID: 39446989
Inhibition of integrin αvβ6 is a promising approach to the treatment of fibrotic disease such as idiopathic pulmonary fibrosis. Screening a small library combining head groups that stabilize the bent-closed...
3.
Lemay S, Montesinos M, Grobs Y, Yokokawa T, Shimauchi T, Romanet C, et al.
bioRxiv
. 2024 Jun;
PMID: 38854025
One Sentence Summary: The α5β1 integrin plays a crucial role in pulmonary vascular remodeling.
4.
Grimster N, Gingipalli L, Balazs A, Barlaam B, Boiko S, Boyd S, et al.
Bioorg Med Chem Lett
. 2023 Jun;
91:129352.
PMID: 37270074
Spleen tyrosine kinase (SYK) is a non-receptor cytoplasmic kinase. Due to its pivotal role in B cell receptor and Fc-receptor signalling, inhibition of SYK has been a target of interest...
5.
Kawatkar S, Barlaam B, Kemmitt P, Simpson I, Watson D, Wang P, et al.
Bioorg Med Chem Lett
. 2020 Jul;
30(18):127393.
PMID: 32721854
Spleen Tyrosine Kinase (SYK) is a well-studied enzyme with therapeutic applications in oncology and autoimmune diseases. We identified an azabenzimidazole (ABI) series of SYK inhibitors by mining activity data of...
6.
Grimster N, Gingipalli L, Barlaam B, Su Q, Zheng X, Watson D, et al.
Bioorg Med Chem Lett
. 2020 Jul;
30(19):127433.
PMID: 32717371
Spleen tyrosine kinase (SYK) is a non-receptor cytosolic kinase. Due to its pivotal role in B cell receptor and Fc-receptor signaling, inhibition of SYK has been targeted in a variety...
7.
Ocampo J, Hamp A, Rhodes A, Smart J, Pemmaraju R, Poschman K, et al.
J Acquir Immune Defic Syndr
. 2019 Aug;
82 Suppl 1:S13-S19.
PMID: 31425390
Background: Focused attention on Data to Care underlines the importance of high-quality HIV surveillance data. This study identified the number of total duplicate and exact duplicate HIV case records in...
8.
Gingipalli L, Block M, Bao L, Cooke E, Dakin L, Denz C, et al.
Bioorg Med Chem Lett
. 2018 Mar;
28(8):1336-1341.
PMID: 29559278
The design and synthesis of a novel series of 2,6-disubstituted pyrazine derivatives as CK2 kinase inhibitors is described. Structure-guided optimization of a 5-substituted-3-thiophene carboxylic acid screening hit (3a) led to...
9.
Shaw J, Leveridge M, Norling C, Karen J, Molina D, ONeill D, et al.
Sci Rep
. 2018 Jan;
8(1):163.
PMID: 29317749
Androgen Receptor (AR) is a key driver in prostate cancer. Direct targeting of AR has valuable therapeutic potential. However, the lack of disease relevant cellular methodologies capable of discriminating between...
10.
Scott J, Degorce S, Anjum R, Culshaw J, Davies R, Davies N, et al.
J Med Chem
. 2017 Nov;
60(24):10071-10091.
PMID: 29172502
Herein we report the optimization of a series of pyrrolopyrimidine inhibitors of interleukin-1 receptor associated kinase 4 (IRAK4) using X-ray crystal structures and structure based design to identify and optimize...