RNA-Puzzles: a CASP-like Evaluation of RNA Three-dimensional Structure Prediction

Overview

Journal RNA

Specialty Molecular Biology

Date 2012 Feb 25

PMID 22361291

Citations 141

Authors

Jose Almeida Cruz

Marc-Frederick Blanchet

Michal Boniecki

Janusz M Bujnicki

Shi-Jie Chen

Song Cao

Rhiju Das

Feng Ding

Nikolay V Dokholyan

Samuel Coulbourn Flores

Lili Huang

Christopher A Lavender

Veronique Lisi

Francois Major

Katarzyna Mikolajczak

Dinshaw J Patel

Anna Philips

Tomasz Puton

John SantaLucia

Fredrick Sijenyi

Thomas Hermann

Kristian Rother

Magdalena Rother

Alexander Serganov

Marcin Skorupski

Tomasz Soltysinski

Parin Sripakdeevong

Irina Tuszynska

Kevin M Weeks

Christina Waldsich

Michael Wildauer

Neocles B Leontis

Eric Westhof

Affiliations

Soon will be listed here.

Abstract

We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.

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