Kevin M Weeks
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Explore the profile of Kevin M Weeks including associated specialties, affiliations and a list of published articles.
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156
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8816
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Recent Articles
1.
Haack D, Rudolfs B, Jin S, Khitun A, Weeks K, Toor N
Nat Commun
. 2025 Jan;
16(1):880.
PMID: 39837824
Cryo-EM structure determination of protein-free RNAs has remained difficult with most attempts yielding low to moderate resolution and lacking nucleotide-level detail. These difficulties are compounded for small RNAs as cryo-EM...
2.
Hao X, Chen Y, Sahu D, Przanowska R, Weidmann C, Nardi I, et al.
bioRxiv
. 2025 Jan;
PMID: 39764029
The 1.7 kb DRAIC long noncoding RNA inhibits tumor growth, inhibits cancer cell invasion, migration, colony formation and interacts with IKK (IκB kinase) subunits, inhibiting the phosphorylation and degradation of...
3.
Waldern J, Taylor C, Giannetti C, Irving P, Allen S, Zhu M, et al.
bioRxiv
. 2024 Dec;
PMID: 39713457
Biogenesis of circular RNA usually involves a backsplicing reaction where the downstream donor site is ligated to the upstream acceptor site by the spliceosome. For this reaction to occur, it...
4.
Felder S, Nelson I, Hatfield B, Weeks K
RNA
. 2024 Dec;
31(2):143-149.
PMID: 39662963
Structures in the 5' untranslated regions (UTRs) of mRNAs can physically modulate translation efficiency by impeding the scanning ribosome or by sequestering the translational start site. We assessed the impact...
5.
Anczukow O, Allain F, Angarola B, Black D, Brooks A, Cheng C, et al.
Nat Rev Cancer
. 2024 Oct;
24(12):887-905.
PMID: 39384951
Splicing factors are affected by recurrent somatic mutations and copy number variations in several types of haematologic and solid malignancies, which is often seen as prima facie evidence that splicing...
6.
Tan A, Irving P, Koehn J, Jin S, Qiu D, Weeks K
Biochemistry
. 2024 Oct;
63(20):2648-2657.
PMID: 39359229
Single-molecule correlated chemical probing (smCCP) is an experimentally concise strategy for characterizing higher-order structural interactions in RNA. smCCP data yield rich, but complex, information about base pairing, conformational ensembles, and...
7.
Schneekloth Jr J, Yang M, Prestwood P, Passalacqua L, Balaratnam S, Fullenkamp C, et al.
Res Sq
. 2024 Aug;
PMID: 39149476
Fluorogenic RNAs such as the Mango aptamers are uniquely powerful tools for imaging RNA. A central challenge has been to develop brighter, more specific, and higher affinity aptamer-ligand systems for...
8.
Arney J, Laederach A, Weeks K
Curr Opin Struct Biol
. 2024 Jul;
88:102877.
PMID: 39024941
RNA molecules fold to form complex internal structures. Many of these RNA structures populate ensembles with rheostat-like properties, with each state having a distinct function. Until recently, analysis of RNA...
9.
Haack D, Rudolfs B, Jin S, Weeks K, Toor N
bioRxiv
. 2024 Jun;
PMID: 38915706
Cryo-EM structure determination of protein-free RNAs has remained difficult with most attempts yielding low to moderate resolution and lacking nucleotide-level detail. These difficulties are compounded for small RNAs as cryo-EM...
10.
Irving P, Weeks K
Nucleic Acids Res
. 2024 Feb;
52(5):2231-2241.
PMID: 38348910
Chemical probing technologies enable high-throughput examination of diverse structural features of RNA, including local nucleotide flexibility, RNA secondary structure, protein and ligand binding, through-space interaction networks, and multistate structural ensembles....