John L Rinn
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Explore the profile of John L Rinn including associated specialties, affiliations and a list of published articles.
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154
Citations
46003
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Recent Articles
1.
Hasenbein T, Hoelzl S, Smith Z, Gerhardinger C, Gonner M, Aguilar-Pimentel A, et al.
Nat Commun
. 2024 Dec;
15(1):10631.
PMID: 39638999
The lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci...
2.
Much C, Lasda E, Pereira I, Vallery T, Ramirez D, Lewandowski J, et al.
Nat Commun
. 2024 Aug;
15(1):6821.
PMID: 39122712
Numerous studies have now demonstrated that lncRNAs can influence gene expression programs leading to cell and organismal phenotypes. Typically, lncRNA perturbations and concomitant changes in gene expression are measured on...
3.
Whited A, Jungreis I, Allen J, Cleveland C, Mudge J, Kellis M, et al.
Biophys Rep (N Y)
. 2024 Jun;
4(3):100167.
PMID: 38909903
Significant efforts have been made to characterize the biophysical properties of proteins. Small proteins have received less attention because their annotation has historically been less reliable. However, recent improvements in...
4.
Lee Y, Hass E, Campodonico W, Lee Y, Lasda E, Shah J, et al.
Nucleic Acids Res
. 2024 May;
52(10):e48.
PMID: 38726866
Many of the biological functions performed by RNA are mediated by RNA-binding proteins (RBPs), and understanding the molecular basis of these interactions is fundamental to biology. Here, we present massively...
5.
Whited A, Jungreis I, Allen J, Cleveland C, Mudge J, Kellis M, et al.
bioRxiv
. 2024 Apr;
PMID: 38659920
Significant efforts have been made to characterize the biophysical properties of proteins. Small proteins have received less attention because their annotation has historically been less reliable. However, recent improvements in...
6.
Normandin E, Triana S, Raju S, Lan T, Lagerborg K, Rudy M, et al.
Cell Genom
. 2024 Jan;
3(12):100440.
PMID: 38169842
Ebola virus (EBOV) causes Ebola virus disease (EVD), marked by severe hemorrhagic fever; however, the mechanisms underlying the disease remain unclear. To assess the molecular basis of EVD across time,...
7.
High-throughput functional analysis of regulatory variants using a massively parallel reporter assay
Delfosse K, Gerhardinger C, Rinn J, Maass P
STAR Protoc
. 2023 Nov;
4(4):102731.
PMID: 37980569
Association studies describe genetic associations between noncoding variants and disease susceptibility; however, they do not provide functional insight into the underlying molecular mechanisms of these variants. We present a protocol...
8.
Long Y, Hwang T, Gooding A, Goodrich K, Hanson S, Vallery T, et al.
bioRxiv
. 2023 Aug;
PMID: 37645830
Polycomb Repressive Complex 2 (PRC2), an important histone modifier and epigenetic repressor, has been known to interact with RNA for almost two decades. In our previous publication (Long, Hwang et...
9.
Santus L, Sopena-Rios M, Garcia-Perez R, Lin A, Adams G, Barnes K, et al.
Nat Commun
. 2023 Jun;
14(1):3866.
PMID: 37391481
Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are pivotal mediators of the immune response, yet little is known about their properties at the single-cell level. Here,...
10.
Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, et al.
Elife
. 2023 Jan;
12.
PMID: 36719724
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of...