A CeRNA Hypothesis: the Rosetta Stone of a Hidden RNA Language?

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2011 Aug 2

PMID 21802130

Citations 3855

Authors

Leonardo Salmena

Laura Poliseno

Yvonne Tay

Lev Kats

Pier Paolo Pandolfi

Affiliations

Soon will be listed here.

Abstract

Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

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