The Role of Long Non-Coding RNA in the Pathogenesis of Psoriasis

Overview

Journal Noncoding RNA

Date 2025 Jan 23

PMID 39846685

Authors

Kajetan Kielbowski

Anna Jedrasiak

Estera Bakinowska

Andrzej Pawlik

Affiliations

Soon will be listed here.

Abstract

Psoriasis is a chronic immune-mediated disease with complex pathogenesis. The altered proliferation and differentiation of keratinocytes, together with the activity of dendritic cells and T cells, are crucial drivers of psoriasis progression. Long non-coding RNAs (lncRNAs) are composed of over 200 nucleotides and exert a large variety of functions, including the regulation of gene expression. Under pathological conditions, the expression of lncRNAs is frequently dysregulated. Recent studies demonstrated that lncRNAs significantly affect major cellular processes, and their aberrant expression is likely involved in the pathogenesis of various disorders. In this review, we will discuss the role of lncRNAs in the pathophysiology of psoriasis. We will summarize recent studies that investigated the relationships between lncRNAs and keratinocyte proliferation and pro-inflammatory responses.

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