Vitamin B12 in Health and Disease

Overview

Journal Nutrients

Date 2012 Jan 19

PMID 22254022

Citations 129

Authors

Fiona OLeary

Samir Samman

Affiliations

Soon will be listed here.

Abstract

Vitamin B(12) is essential for DNA synthesis and for cellular energy production.This review aims to outline the metabolism of vitamin B(12), and to evaluate the causes and consequences of sub-clinical vitamin B(12) deficiency. Vitamin B(12) deficiency is common, mainly due to limited dietary intake of animal foods or malabsorption of the vitamin. Vegetarians are at risk of vitamin B(12) deficiency as are other groups with low intakes of animal foods or those with restrictive dietary patterns. Malabsorption of vitamin B(12) is most commonly seen in the elderly, secondary to gastric achlorhydria. The symptoms of sub-clinical deficiency are subtle and often not recognized. The long-term consequences of sub-clinical deficiency are not fully known but may include adverse effects on pregnancy outcomes, vascular, cognitive, bone and eye health.

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References

Gaber K, Farag M, Soliman S, El-Bassyouni H, El-Kamah G . Maternal vitamin B12 and the risk of fetal neural tube defects in Egyptian patients. Clin Lab. 2007; 53(1-2):69-75. View

. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002; 288(16):2015-22. DOI: 10.1001/jama.288.16.2015. View

Lewis M, Miller L, Johnson M, Dolce E, Allen R, Stabler S . Elevated methylmalonic acid is related to cognitive impairement in older adults enrolled in an elderly nutrition program. J Nutr Elder. 2005; 24(3):47-65. DOI: 10.1300/J052v24n03_05. View

Valuck R, Ruscin J . A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults. J Clin Epidemiol. 2004; 57(4):422-8. DOI: 10.1016/j.jclinepi.2003.08.015. View

Quinlivan E, McPartlin J, McNulty H, Ward M, Strain J, Weir D . Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Lancet. 2002; 359(9302):227-8. DOI: 10.1016/s0140-6736(02)07439-1. View

Albert C, Cook N, Gaziano J, Zaharris E, MacFadyen J, Danielson E . Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA. 2008; 299(17):2027-36. PMC: 2684623. DOI: 10.1001/jama.299.17.2027. View

Antoniades C, Antonopoulos A, Tousoulis D, Marinou K, Stefanadis C . Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J. 2008; 30(1):6-15. DOI: 10.1093/eurheartj/ehn515. View

Tucker K, Hannan M, Qiao N, Jacques P, Selhub J, Cupples L . Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res. 2004; 20(1):152-8. DOI: 10.1359/JBMR.041018. View

HEYSSEL R, Bozian R, Darby W, Bell M . Vitamin B12 turnover in man. The assimilation of vitamin B12 from natural foodstuff by man and estimates of minimal daily dietary requirements. Am J Clin Nutr. 1966; 18(3):176-84. DOI: 10.1093/ajcn/18.3.176. View

10.

Zhou J, Austin R . Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms. Biofactors. 2009; 35(2):120-9. DOI: 10.1002/biof.17. View

11.

Suarez L, Hendricks K, Felkner M, Gunter E . Maternal serum B12 levels and risk for neural tube defects in a Texas-Mexico border population. Ann Epidemiol. 2003; 13(2):81-8. DOI: 10.1016/s1047-2797(02)00267-3. View

12.

Matteini A, Walston J, Fallin M, Bandeen-Roche K, Kao W, Semba R . Markers of B-vitamin deficiency and frailty in older women. J Nutr Health Aging. 2008; 12(5):303-8. PMC: 2739594. DOI: 10.1007/BF02982659. View

13.

Dhonukshe-Rutten R, Pluijm S, de Groot L, Lips P, Smit J, van Staveren W . Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res. 2005; 20(6):921-9. DOI: 10.1359/JBMR.050202. View

14.

Zhang T, Xin R, Gu X, Wang F, Pei L, Lin L . Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr. 2008; 12(5):680-6. DOI: 10.1017/S1368980008002735. View

15.

Stabler S, Allen R . Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr. 2004; 24:299-326. DOI: 10.1146/annurev.nutr.24.012003.132440. View

16.

Kirke P, Molloy A, Daly L, Burke H, Weir D, Scott J . Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med. 1993; 86(11):703-8. View

17.

den Elzen W, Groeneveld Y, de Ruijter W, Souverijn J, le Cessie S, Assendelft W . Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals. Aliment Pharmacol Ther. 2008; 27(6):491-7. DOI: 10.1111/j.1365-2036.2008.03601.x. View

18.

Dharmarajan T, Kanagala M, Murakonda P, Lebelt A, Norkus E . Do acid-lowering agents affect vitamin B12 status in older adults?. J Am Med Dir Assoc. 2008; 9(3):162-7. DOI: 10.1016/j.jamda.2007.10.004. View

19.

Carmel R . How I treat cobalamin (vitamin B12) deficiency. Blood. 2008; 112(6):2214-21. PMC: 2532799. DOI: 10.1182/blood-2008-03-040253. View

20.

Malouf R, Areosa Sastre A . Vitamin B12 for cognition. Cochrane Database Syst Rev. 2003; (3):CD004326. DOI: 10.1002/14651858.CD004326. View