Assessment of Cytotoxin-associated Gene A (Cag A) Protein and Its Association with Ferritin and Vitamin B12 Deficiencies Among Adult Healthy Asymptomatic Residents in Sharjah, United Arab Emirates

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Jun 17

PMID 38882276

Authors

Om Kolthoom M Weisy

Reena A Kedia

Ibrahim Mahmoud

Raed O Abu Odeh

Bashair M Mussa

Salah Abusnana

Sameh S M Soliman

Jibran Sualeh Muhammad

Mohamad Hamad

Rose Ghemrawi

Ghalia Khoder

Affiliations

Soon will be listed here.

Abstract

The United Arab Emirates (UAE) serves as an effective epidemiological site for assessing () infection due to its diverse population. However, comprehensive studies on the prevalence of in the UAE are notably scarce. In depth prevalence studies are needed as a preventive measure against gastric cancer and other emerging extra gastric diseases associated with infection. Aim: This study aimed to assess infection and its virulent oncoprotein, the Cytotoxin-Associated Gene (Cag A) and its association with ferritin and vitamin B12 deficiencies. : The study was conducted on 1094 healthy asymptomatic volunteers residents in the Sharjah Emirate, UAE. Enzyme-linked immunosorbent assay (ELISA) was performed to assess infection using antibodies (IgG), and detection of CagA protein using Cag A antibody (IgG) in the human serum. Ferritin and vitamin B12 serum levels were assessed and correlated to infection. : This study focuses mainly on the assessment of and its virulent factor CagA, in relation to vitamin B12 and ferritin deficiencies. Remarkably, 49.6 % of the participants were detected positive for , with over half of these cases involving CagA positive strains. Notably, among Emirati participants, 76.11 % of those with infection were CagA positive. Statistical analysis revealed a significant correlation between , CagA level, and ferritin/vitamin B12 deficiencies. : These findings emphasize the importance of timely detection and eradication of not only as a preventive strategy against gastric cancer but also as an effective strategy to rescue the adverse effects from ferritin and vitamin B12 deficiencies, thereby improving the overall health outcomes of individuals affected by infection.

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