Gestational Diabetes Mellitus: What Can Medical Nutrition Therapy Do?

Overview

Journal Nutrients

Date 2024 Apr 27

PMID 38674907

Authors

Xiaoyi Wei

Hong Zou

Tingting Zhang

Yanling Huo

Jianzhong Yang

Zhi Wang

Yu Li

Jiuxiang Zhao

Affiliations

Soon will be listed here.

Abstract

Gestational diabetes mellitus (GDM) is one of the common complications during pregnancy. Numerous studies have shown that GDM is associated with a series of adverse effects on both mothers and offspring. Due to the particularity of pregnancy, medical nutrition treatment is considered to be the first choice for the treatment of GDM. This contribution reviews the research progress of medical nutrition treatment in GDM, summarizes the international recommendations on the intake of various nutrients and the influence of nutrients on the prevalence of GDM, and the improvement effect of nutritional intervention on it, in order to provide references for research in related fields of GDM and the targeted development of enteral nutrition.

Citing Articles

Correlations Between Gut Microbiota Composition, Medical Nutrition Therapy, and Insulin Resistance in Pregnancy-A Narrative Review.

Enache R, Rosu O, Profir M, Pavelescu L, Cretoiu S, Gaspar B Int J Mol Sci. 2025; 26(3).

PMID: 39941139 PMC: 11818759. DOI: 10.3390/ijms26031372.

Impact of Gestational Diabetes Mellitus on Fetal Growth and Nutritional Status in Newborns.

Karcz K, Krolak-Olejnik B Nutrients. 2024; 16(23).

PMID: 39683486 PMC: 11643953. DOI: 10.3390/nu16234093.

Gestational Diabetes: An Update 60 Years After O'Sullivan and Mahan.

McIntyre H, Kampmann U, Clausen T, Laurie J, Ma R J Clin Endocrinol Metab. 2024; 110(1):e19-e31.

PMID: 39389786 PMC: 11651698. DOI: 10.1210/clinem/dgae709.

References

Sacks F, Carey V, Anderson C, Miller 3rd E, Copeland T, Charleston J . Effects of high vs low glycemic index of dietary carbohydrate on cardiovascular disease risk factors and insulin sensitivity: the OmniCarb randomized clinical trial. JAMA. 2014; 312(23):2531-41. PMC: 4370345. DOI: 10.1001/jama.2014.16658. View

Stover P . Physiology of folate and vitamin B12 in health and disease. Nutr Rev. 2004; 62(6 Pt 2):S3-12. DOI: 10.1111/j.1753-4887.2004.tb00070.x. View

Hanson A, Gregory 3rd J . Folate biosynthesis, turnover, and transport in plants. Annu Rev Plant Biol. 2011; 62:105-25. DOI: 10.1146/annurev-arplant-042110-103819. View

Bhowmik B, Siddique T, Majumder A, Mdala I, Hossain I, Hassan Z . Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh. BMC Pregnancy Childbirth. 2019; 19(1):413. PMC: 6849244. DOI: 10.1186/s12884-019-2571-5. View

. Gestational diabetes mellitus. Diabetes Care. 2002; 23 Suppl 1:S77-9. View

Zimmermann M, Jooste P, Pandav C . Iodine-deficiency disorders. Lancet. 2008; 372(9645):1251-62. DOI: 10.1016/S0140-6736(08)61005-3. View

Landon M, Spong C, Thom E, Carpenter M, Ramin S, Casey B . A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009; 361(14):1339-48. PMC: 2804874. DOI: 10.1056/NEJMoa0902430. View

Williamson J, Arthurs A, Smith M, Roberts C, Jankovic-Karasoulos T . High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus. Nutrients. 2022; 14(19). PMC: 9573299. DOI: 10.3390/nu14193930. View

Vasile F, Preda A, Stefan A, Vladu M, Fortofoiu M, Clenciu D . An Update of Medical Nutrition Therapy in Gestational Diabetes Mellitus. J Diabetes Res. 2021; 2021:5266919. PMC: 8616668. DOI: 10.1155/2021/5266919. View

10.

Al-Gubory K . Mitochondria: omega-3 in the route of mitochondrial reactive oxygen species. Int J Biochem Cell Biol. 2012; 44(9):1569-73. DOI: 10.1016/j.biocel.2012.06.003. View

11.

Ryckman K, Spracklen C, Smith C, Robinson J, Saftlas A . Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis. BJOG. 2015; 122(5):643-51. DOI: 10.1111/1471-0528.13261. View

12.

Martin-Estal I, Castorena-Torres F . Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis?. Front Endocrinol (Lausanne). 2022; 13:916042. PMC: 9259869. DOI: 10.3389/fendo.2022.916042. View

13.

Bao W, Bowers K, Tobias D, Hu F, Zhang C . Prepregnancy dietary protein intake, major dietary protein sources, and the risk of gestational diabetes mellitus: a prospective cohort study. Diabetes Care. 2013; 36(7):2001-8. PMC: 3687314. DOI: 10.2337/dc12-2018. View

14.

Brand-Miller J, Hayne S, Petocz P, Colagiuri S . Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials. Diabetes Care. 2003; 26(8):2261-7. DOI: 10.2337/diacare.26.8.2261. View

15.

Kintiraki E, Goulis D . Gestational diabetes mellitus: Multi-disciplinary treatment approaches. Metabolism. 2018; 86:91-101. DOI: 10.1016/j.metabol.2018.03.025. View

16.

Boden G, Chen X, Ruiz J, White J, Rossetti L . Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest. 1994; 93(6):2438-46. PMC: 294452. DOI: 10.1172/JCI117252. View

17.

Duarte-Gardea M, Gonzales-Pacheco D, Reader D, Thomas A, Wang S, Gregory R . Academy of Nutrition and Dietetics Gestational Diabetes Evidence-Based Nutrition Practice Guideline. J Acad Nutr Diet. 2018; 118(9):1719-1742. DOI: 10.1016/j.jand.2018.03.014. View

18.

Ge Y, Zadeh M, Mohamadzadeh M . Vitamin B12 Regulates the Transcriptional, Metabolic, and Epigenetic Programing in Human Ileal Epithelial Cells. Nutrients. 2022; 14(14). PMC: 9321803. DOI: 10.3390/nu14142825. View

19.

Buchanan T, Xiang A, Page K . Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol. 2012; 8(11):639-49. PMC: 4404707. DOI: 10.1038/nrendo.2012.96. View

20.

Colletti A, Cravotto G, Citi V, Martelli A, Testai L, Cicero A . Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications. Mar Drugs. 2021; 19(6). PMC: 8226823. DOI: 10.3390/md19060306. View