Genome-wide Association Study Identifies Five Loci Associated with Susceptibility to Pancreatic Cancer in Chinese Populations

Overview

Journal Nat Genet

Specialty Genetics

Date 2011 Dec 14

PMID 22158540

Citations 108

Authors

Chen Wu

Xiaoping Miao

Liming Huang

Xu Che

Guoliang Jiang

Dianke Yu

Xianghong Yang

Guangwen Cao

Zhibin Hu

Yongjian Zhou

Chaohui Zuo

Chunyou Wang

Xianghong Zhang

Yifeng Zhou

Xianjun Yu

Wanjin Dai

Zhaoshen Li

Hongbing Shen

Luming Liu

Yanling Chen

Sheng Zhang

Xiaoqi Wang

Kan Zhai

Jiang Chang

Yu Liu

Menghong Sun

Wei Cao

Jun Gao

Ying Ma

Xiongwei Zheng

Siu Tim Cheung

Yongfeng Jia

Jian Xu

Wen Tan

Ping Zhao

Tangchun Wu

Chengfeng Wang

Dongxin Lin

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.

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