Body Mass Index, Effect Modifiers, and Risk of Pancreatic Cancer: a Pooled Study of Seven Prospective Cohorts

Overview

Journal Cancer Causes Control

Specialties Oncology
Public Health

Date 2010 Apr 13

PMID 20383573

Citations 54

Authors

Li Jiao

Amy Berrington de Gonzalez

Patricia Hartge

Ruth M Pfeiffer

Yikyung Park

D Michal Freedman

Mitchell H Gail

Michael C R Alavanja

Demetrius Albanes

Laura E Beane Freeman

Wong-Ho Chow

Wen-Yi Huang

Richard B Hayes

Jane A Hoppin

Bu-Tian Ji

Michael F Leitzmann

Martha S Linet

Cari L Meinhold

Catherine Schairer

Arthur Schatzkin

Jarmo Virtamo

Stephanie J Weinstein

Wei Zheng

Rachael Z Stolzenberg-Solomon

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes.

Methods: In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9 years of follow-up. Cox proportional hazard regression models were used in data analysis.

Results: In a random-effects meta-analysis, for every 5 kg/m(2) increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99-1.13) for men and 1.12 (95% CI 1.05-1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to <25), the adjusted RR was 1.13 (95% CI 1.03-1.23) for overweight (BMI: 25 to <30) and 1.19 (95% CI 1.05-1.35) for obesity class I (BMI: 30 to <35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5 kg/m(2) increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction = 0.08).

Conclusion: The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.

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