Seasonal Variation in 25-hydroxyvitamin D Concentrations in the Cardiovascular Health Study

Overview

Journal Am J Epidemiol

Publisher Oxford University Press

Specialty Public Health

Date 2011 Nov 25

PMID 22112344

Citations 60

Authors

Abigail B Shoben

Bryan Kestenbaum

Gregory Levin

Andrew N Hoofnagle

Bruce M Psaty

David S Siscovick

Ian H de Boer

Affiliations

Soon will be listed here.

Abstract

Low circulating concentrations of 25-hydroxyvitamin D (25(OH)D) are associated with adverse health outcomes in diverse populations. However, 25(OH)D concentrations vary seasonally with varying exposure to sunlight, so single measurements may poorly reflect long-term 25(OH)D exposure. The authors investigated cyclical trends in average serum 25(OH)D concentrations among 2,298 individuals enrolled in the Cardiovascular Health Study of community-based older adults (1992-1993). A sinusoidal model closely approximated observed 25(OH)D concentrations and fit the data significantly better than did a mean model (P < 0.0001). The mean annual 25(OH)D concentration was 25.1 ng/mL (95% confidence interval: 24.7, 25.5), and the mean peak-trough difference was 9.6 ng/mL (95% confidence interval: 8.5, 10.7). Male sex, higher latitude of study site, and greater physical activity levels were associated with larger peak-trough difference in 25(OH)D concentration (each P < 0.05). Serum concentrations of intact parathyroid hormone and bone-specific alkaline phosphatase also varied in a sinusoidal fashion (P < 0.0001), inversely to 25(OH)D. In conclusion, serum 25(OH)D varies in a sinusoidal manner, with large seasonal differences relative to mean concentration and laboratory evidence of biologic sequelae. Single 25(OH)D measurements might not capture overall vitamin D status, and the extent of misclassification could vary by demographic and behavioral factors. Accounting for collection time may reduce bias in research studies and improve decision-making in clinical care.

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References

de Boer I, Ioannou G, Kestenbaum B, Brunzell J, Weiss N . 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis. 2007; 50(1):69-77. DOI: 10.1053/j.ajkd.2007.04.015. View

Kamycheva E, Sundsfjord J, Jorde R . Serum parathyroid hormone level is associated with body mass index. The 5th Tromsø study. Eur J Endocrinol. 2004; 151(2):167-72. DOI: 10.1530/eje.0.1510167. View

Looker A, Pfeiffer C, Lacher D, Schleicher R, Picciano M, Yetley E . Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr. 2008; 88(6):1519-27. PMC: 2745830. DOI: 10.3945/ajcn.2008.26182. View

Fried L, Borhani N, Enright P, Furberg C, Gardin J, Kronmal R . The Cardiovascular Health Study: design and rationale. Ann Epidemiol. 1991; 1(3):263-76. DOI: 10.1016/1047-2797(91)90005-w. View

Phinney K . Development of a standard reference material for vitamin D in serum. Am J Clin Nutr. 2008; 88(2):511S-512S. DOI: 10.1093/ajcn/88.2.511S. View

. Standards of medical care in diabetes--2007. Diabetes Care. 2006; 30 Suppl 1:S4-S41. DOI: 10.2337/dc07-S004. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Kestenbaum B, Katz R, de Boer I, Hoofnagle A, Sarnak M, Shlipak M . Vitamin D, parathyroid hormone, and cardiovascular events among older adults. J Am Coll Cardiol. 2011; 58(14):1433-41. PMC: 3210558. DOI: 10.1016/j.jacc.2011.03.069. View

Wang Y, Jacobs E, McCullough M, Rodriguez C, Thun M, Calle E . Comparing methods for accounting for seasonal variability in a biomarker when only a single sample is available: insights from simulations based on serum 25-hydroxyvitamin d. Am J Epidemiol. 2009; 170(1):88-94. DOI: 10.1093/aje/kwp086. View

10.

Jorde R, Sneve M, Hutchinson M, Emaus N, Figenschau Y, Grimnes G . Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol. 2010; 171(8):903-8. DOI: 10.1093/aje/kwq005. View

11.

Robinson-Cohen C, Katz R, Mozaffarian D, Dalrymple L, de Boer I, Sarnak M . Physical activity and rapid decline in kidney function among older adults. Arch Intern Med. 2009; 169(22):2116-23. PMC: 2878734. DOI: 10.1001/archinternmed.2009.438. View

12.

Mikulich S, Zerbe G, Jones R, Crowley T . Comparing linear and nonlinear mixed model approaches to cosinor analysis. Stat Med. 2003; 22(20):3195-211. DOI: 10.1002/sim.1560. View

13.

Agborsangaya C, Toriola A, Grankvist K, Surcel H, Holl K, Parkkila S . The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione. Nutr Cancer. 2010; 62(1):51-7. DOI: 10.1080/01635580903191460. View

14.

Robinson-Cohen C, Katz R, Hoofnagle A, Cauley J, Furberg C, Robbins J . Mineral metabolism markers and the long-term risk of hip fracture: the cardiovascular health study. J Clin Endocrinol Metab. 2011; 96(7):2186-93. PMC: 3135189. DOI: 10.1210/jc.2010-2878. View

15.

Wortsman J, Matsuoka L, Chen T, Lu Z, Holick M . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72(3):690-3. DOI: 10.1093/ajcn/72.3.690. View

16.

Sherman S, Hollis B, Tobin J . Vitamin D status and related parameters in a healthy population: the effects of age, sex, and season. J Clin Endocrinol Metab. 1990; 71(2):405-13. DOI: 10.1210/jcem-71-2-405. View

17.

Stevens L, Coresh J, Schmid C, Feldman H, Froissart M, Kusek J . Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis. 2008; 51(3):395-406. PMC: 2390827. DOI: 10.1053/j.ajkd.2007.11.018. View

18.

Armas L, Dowell S, Akhter M, Duthuluru S, Huerter C, Hollis B . Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color. J Am Acad Dermatol. 2007; 57(4):588-93. DOI: 10.1016/j.jaad.2007.03.004. View

19.

Bolland M, Grey A, Ames R, Mason B, Horne A, Gamble G . The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. Am J Clin Nutr. 2007; 86(4):959-64. DOI: 10.1093/ajcn/86.4.959. View

20.

Wang T, Zhang F, Richards J, Kestenbaum B, van Meurs J, Berry D . Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010; 376(9736):180-8. PMC: 3086761. DOI: 10.1016/S0140-6736(10)60588-0. View