Clinical and Molecular Characteristics of Extended-spectrum-beta-lactamase-producing Escherichia Coli Causing Bacteremia in the Rotterdam Area, Netherlands

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2011 Apr 20

PMID 21502612

Citations 36

Authors

Akke K van der Bij

Gisele Peirano

Wil H F Goessens

Eric R van der Vorm

M van Westreenen

Johann D D Pitout

Affiliations

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Abstract

We investigated the clinical and molecular characteristics of bacteremia caused by extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli over a 2-year period (2008 to 2009) in the Rotterdam region (including 1 teaching hospital and 2 community hospitals) of Netherlands. The majority of patients presented with community onset urinary and intra-abdominal infections, with an increase in prevalence during 2009. The majority of E. coli isolates produced CTX-M-15, and 4 sequence types (ST38, ST131, ST405, and ST648) predominated. There were significant differences in clinical and molecular characteristics between the 2 community hospitals.

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