Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease

Overview

Journal PLoS Curr

Specialty General Medicine

Date 2011 Apr 12

PMID 21479110

Citations 23

Authors

Stephen Oakeshott

Fuat Balci

Igor Filippov

Carol Murphy

Russell Port

David Connor

Ahmad Paintdakhi

Joseph LeSauter

Liliana Menalled

Sylvie Ramboz

Seung Kwak

David Howland

Rae Silver

Dani Brunner

Affiliations

Soon will be listed here.

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD.

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