Aβ(1-42) Inhibition of LTP is Mediated by a Signaling Pathway Involving Caspase-3, Akt1 and GSK-3β

Overview

Journal Nat Neurosci

Date 2011 Mar 29

PMID 21441921

Citations 169

Authors

Jihoon Jo

Daniel J Whitcomb

Kimberly Moore Olsen

Talitha L Kerrigan

Shih-Ching Lo

Gilles Bru-Mercier

Bryony Dickinson

Sarah Scullion

Morgan Sheng

Graham Collingridge

Kwangwook Cho

Affiliations

Soon will be listed here.

Abstract

Amyloid-β(1-42) (Aβ) is thought to be a major mediator of the cognitive deficits in Alzheimer's disease. The ability of Aβ to inhibit hippocampal long-term potentiation provides a cellular correlate of this action, but the underlying molecular mechanism is only partially understood. We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3β is an important mediator of this effect in rats and mice.

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