Pathways Towards and Away from Alzheimer's Disease

Overview

Journal Nature

Specialty Science

Date 2004 Aug 6

PMID 15295589

Citations 1009

Authors

Mark P Mattson

Affiliations

Soon will be listed here.

Abstract

Slowly but surely, Alzheimer's disease (AD) patients lose their memory and their cognitive abilities, and even their personalities may change dramatically. These changes are due to the progressive dysfunction and death of nerve cells that are responsible for the storage and processing of information. Although drugs can temporarily improve memory, at present there are no treatments that can stop or reverse the inexorable neurodegenerative process. But rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies.

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References

Mattson M . Gene-diet interactions in brain aging and neurodegenerative disorders. Ann Intern Med. 2003; 139(5 Pt 2):441-4. DOI: 10.7326/0003-4819-139-5_part_2-200309021-00012. View

Bush A, Masters C, Tanzi R . Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. Proc Natl Acad Sci U S A. 2003; 100(20):11193-4. PMC: 208731. DOI: 10.1073/pnas.2135061100. View

Mayeux R . Epidemiology of neurodegeneration. Annu Rev Neurosci. 2003; 26:81-104. DOI: 10.1146/annurev.neuro.26.043002.094919. View

Song S, Kim S, Hong Y, Jo D, Lee J, Shim S . Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity. Mol Cell. 2003; 12(3):553-63. DOI: 10.1016/j.molcel.2003.08.005. View

Eckert A, Keil U, Marques C, Bonert A, Frey C, Schussel K . Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease. Biochem Pharmacol. 2003; 66(8):1627-34. DOI: 10.1016/s0006-2952(03)00534-3. View

John V, Beck J, Bienkowski M, Sinha S, Heinrikson R . Human beta-secretase (BACE) and BACE inhibitors. J Med Chem. 2003; 46(22):4625-30. DOI: 10.1021/jm030247h. View

Mandelkow E, Stamer K, Vogel R, Thies E, Mandelkow E . Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiol Aging. 2003; 24(8):1079-85. DOI: 10.1016/j.neurobiolaging.2003.04.007. View

Ritchie C, Bush A, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L . Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol. 2003; 60(12):1685-91. DOI: 10.1001/archneur.60.12.1685. View

Yao P . Synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer's disease. Trends Neurosci. 2003; 27(1):24-9. DOI: 10.1016/j.tins.2003.10.012. View

10.

Zandi P, Anthony J, Khachaturian A, Stone S, Gustafson D, Tschanz J . Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol. 2004; 61(1):82-8. DOI: 10.1001/archneur.61.1.82. View

11.

Cutler R, Kelly J, Storie K, Pedersen W, Tammara A, Hatanpaa K . Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A. 2004; 101(7):2070-5. PMC: 357053. DOI: 10.1073/pnas.0305799101. View

12.

Kruman I, Wersto R, Cardozo-Pelaez F, Smilenov L, Chan S, Chrest F . Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron. 2004; 41(4):549-61. DOI: 10.1016/s0896-6273(04)00017-0. View

13.

Yang Y, Cook D . Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons. Neuroscience. 2004; 124(3):501-5. DOI: 10.1016/j.neuroscience.2003.11.029. View

14.

DeKosky S, Scheff S . Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol. 1990; 27(5):457-64. DOI: 10.1002/ana.410270502. View

15.

Yankner B, Duffy L, Kirschner D . Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science. 1990; 250(4978):279-82. DOI: 10.1126/science.2218531. View

16.

Saito K, Elce J, Hamos J, Nixon R . Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci U S A. 1993; 90(7):2628-32. PMC: 46148. DOI: 10.1073/pnas.90.7.2628. View

17.

Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner B . Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000; 403(6765):98-103. DOI: 10.1038/47513. View

18.

Dodart J, Mathis C, Bales K, Paul S, Ungerer A . Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein. Neurosci Lett. 2000; 277(1):49-52. DOI: 10.1016/s0304-3940(99)00847-2. View

19.

Roses A . A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease. Neurogenetics. 1997; 1(1):3-11. DOI: 10.1007/s100480050001. View

20.

Lu D, Rabizadeh S, Chandra S, Shayya R, Ellerby L, Ye X . A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med. 2000; 6(4):397-404. DOI: 10.1038/74656. View