From Synapses to Circuits and Back: Bridging Levels of Understanding in Animal Models of Alzheimer's Disease

Overview

Journal Eur J Neurosci

Specialty Neurology

Date 2022 Mar 4

PMID 35244297

Authors

Udaysankar Chockanathan

Krishnan Padmanabhan

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by behavioural changes that include memory loss and cognitive decline and is associated with the appearance of amyloid-β plaques and neurofibrillary tangles throughout the brain. Although aspects of the disease percolate across multiple levels of neuronal organization, from the cellular to the behavioural, it is increasingly clear that circuits are a critical junction between the cellular pathology and the behavioural phenotypes that bookend these levels of analyses. In this review, we discuss critical aspects of neural circuit research, beginning with synapses and progressing to network activity and how they influence our understanding of disease processed in AD.

Citing Articles

Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of Aβ pathology.

Chockanathan U, Padmanabhan K PLoS Comput Biol. 2024; 20(5):e1012085.

PMID: 38709845 PMC: 11098488. DOI: 10.1371/journal.pcbi.1012085.

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