Lipocalin-1: a Potential Marker for Noninvasive Aneuploidy Screening

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2011 Feb 18

PMID 21324447

Citations 11

Authors

Susanna McReynolds

Lauren Vanderlinden

John Stevens

Kirk Hansen

William B Schoolcraft

Mandy G Katz-Jaffe

Affiliations

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Abstract

This study has identified the first protein, lipocalin-1, in the secretome of human blastocysts that is associated with chromosome aneuploidy. The development of a noninvasive technique to determine an embryo's developmental competence, including chromosomal constitution, by analysis of spent IVF culture medium will be a powerful tool for embryo selection in assisted reproductive technologies.

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