The Use of Proteomics in Assisted Reproduction

Overview

Journal In Vivo

Specialty Oncology

Date 2017 Apr 26

PMID 28438852

Citations 7

Authors

Ioanna Kosteria

Athanasios K Anagnostopoulos

Christina Kanaka-Gantenbein

George P Chrousos

George T Tsangaris

Affiliations

Soon will be listed here.

Abstract

Despite the explosive increase in the use of Assisted Reproductive Technologies (ART) over the last 30 years, their success rates remain suboptimal. Proteomics is a rapidly-evolving technology-driven science that has already been widely applied in the exploration of human reproduction and fertility, providing useful insights into its physiology and leading to the identification of numerous proteins that may be potential biomarkers and/or treatment targets of a successful ART pregnancy. Here we present a brief overview of the techniques used in proteomic analyses and attempt a comprehensive presentation of recent data from mass spectrometry-based proteomic studies in humans, regarding all components of ARTs, including the male and female gamete, the derived zygote and embryo, the endometrium and, finally, the ART offspring both pre- and postnatally.

Citing Articles

Follicular Fluid Proteomic Analysis of Women Undergoing Assisted Reproduction Suggests That Apolipoprotein A1 Is a Potential Fertility Marker.

Kurdi C, Schmidt J, Horvath-Szalai Z, Mauchart P, Godony K, Varnagy A Int J Mol Sci. 2024; 25(1).

PMID: 38203658 PMC: 10778837. DOI: 10.3390/ijms25010486.

A Comparative Proteomic Analysis to Explore the Influencing Factors on Endometritis Using LC-MS/MS.

Jiang X, Li Z, Chang X, Lian Z, Wang A, Lin P Int J Mol Sci. 2023; 24(12).

PMID: 37373165 PMC: 10298677. DOI: 10.3390/ijms241210018.

Reappraisal of evolving methods in non-invasive prenatal screening: Discovery, biology and clinical utility.

Rather R, Saha S Heliyon. 2023; 9(3):e13923.

PMID: 36879971 PMC: 9984859. DOI: 10.1016/j.heliyon.2023.e13923.

Sperm selection in IVF: the long and winding road from bench to bedside.

Pedrosa M, Furtado M, Ferreira M, Carneiro M JBRA Assist Reprod. 2020; 24(3):332-339.

PMID: 32155013 PMC: 7365522. DOI: 10.5935/1518-0557.20190081.

Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry.

Fu L, An Q, Zhang K, Liu Y, Tong Y, Xu J BMC Urol. 2019; 19(1):133.

PMID: 31842847 PMC: 6916233. DOI: 10.1186/s12894-019-0565-2.

References

Sharma R, Agarwal A, Mohanty G, Hamada A, Gopalan B, Willard B . Proteomic analysis of human spermatozoa proteins with oxidative stress. Reprod Biol Endocrinol. 2013; 11:48. PMC: 3716960. DOI: 10.1186/1477-7827-11-48. View

Scott Jr R, Treff N . Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies. Fertil Steril. 2010; 94(3):791-4. DOI: 10.1016/j.fertnstert.2010.03.041. View

Siva A, Kameshwari D, Singh V, Pavani K, Sundaram C, Rangaraj N . Proteomics-based study on asthenozoospermia: differential expression of proteasome alpha complex. Mol Hum Reprod. 2010; 16(7):452-62. DOI: 10.1093/molehr/gaq009. View

Kolialexi A, Tsangaris G, Papantoniou N, Anagnostopoulos A, Vougas K, Bagiokos V . Application of proteomics for the identification of differentially expressed protein markers for Down syndrome in maternal plasma. Prenat Diagn. 2008; 28(8):691-8. DOI: 10.1002/pd.2040. View

Cecconi D, Lonardoni F, Favretto D, Cosmi E, Tucci M, Visentin S . Changes in amniotic fluid and umbilical cord serum proteomic profiles of foetuses with intrauterine growth retardation. Electrophoresis. 2011; 32(24):3630-7. DOI: 10.1002/elps.201100256. View

Ceelen M, van Weissenbruch M, Roos J, Vermeiden J, van Leeuwen F, Delemarre-van de Waal H . Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab. 2007; 92(9):3417-23. DOI: 10.1210/jc.2006-2896. View

Yamakawa K, Yoshida K, Nishikawa H, Kato T, Iwamoto T . Comparative analysis of interindividual variations in the seminal plasma proteome of fertile men with identification of potential markers for azoospermia in infertile patients. J Androl. 2007; 28(6):858-65. DOI: 10.2164/jandrol.107.002824. View

Wang J, Wang J, Zhang H, Shi H, Ma D, Zhao H . Proteomic analysis of seminal plasma from asthenozoospermia patients reveals proteins that affect oxidative stress responses and semen quality. Asian J Androl. 2009; 11(4):484-91. PMC: 3735302. DOI: 10.1038/aja.2009.26. View

Gu B, Zhang J, Wu Y, Zhang X, Tan Z, Lin Y . Proteomic analyses reveal common promiscuous patterns of cell surface proteins on human embryonic stem cells and sperms. PLoS One. 2011; 6(5):e19386. PMC: 3086920. DOI: 10.1371/journal.pone.0019386. View

10.

Xu W, Hu H, Wang Z, Chen X, Yang F, Zhu Z . Proteomic characteristics of spermatozoa in normozoospermic patients with infertility. J Proteomics. 2012; 75(17):5426-36. DOI: 10.1016/j.jprot.2012.06.021. View

11.

Farquhar C, Rishworth J, Brown J, Nelen W, Marjoribanks J . Assisted reproductive technology: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2013; (8):CD010537. DOI: 10.1002/14651858.CD010537.pub2. View

12.

Guo X, Zhao C, Wang F, Zhu Y, Cui Y, Zhou Z . Investigation of human testis protein heterogeneity using 2-dimensional electrophoresis. J Androl. 2010; 31(4):419-29. DOI: 10.2164/jandrol.109.007534. View

13.

McReynolds S, Vanderlinden L, Stevens J, Hansen K, Schoolcraft W, Katz-Jaffe M . Lipocalin-1: a potential marker for noninvasive aneuploidy screening. Fertil Steril. 2011; 95(8):2631-3. DOI: 10.1016/j.fertnstert.2011.01.141. View

14.

Parmar T, Gadkar-Sable S, Savardekar L, Katkam R, Dharma S, Meherji P . Protein profiling of human endometrial tissues in the midsecretory and proliferative phases of the menstrual cycle. Fertil Steril. 2008; 92(3):1091-1103. DOI: 10.1016/j.fertnstert.2008.07.1734. View

15.

Van Vaerenbergh I, Fatemi H, Blockeel C, Van Lommel L, Int Veld P, Schuit F . Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression. Reprod Biomed Online. 2011; 22(3):263-71. DOI: 10.1016/j.rbmo.2010.11.002. View

16.

DeSouza L, Diehl G, Yang E, Guo J, Rodrigues M, Romaschin A . Proteomic analysis of the proliferative and secretory phases of the human endometrium: protein identification and differential protein expression. Proteomics. 2004; 5(1):270-81. DOI: 10.1002/pmic.200400920. View

17.

Zhang Y, Zhang Y, Feng C, Wu Y, Liu A, Sheng J . Comparative proteomic analysis of human placenta derived from assisted reproductive technology. Proteomics. 2008; 8(20):4344-56. DOI: 10.1002/pmic.200800294. View

18.

Larsen W, Wert S, BRUNNER G . A dramatic loss of cumulus cell gap junctions is correlated with germinal vesicle breakdown in rat oocytes. Dev Biol. 1986; 113(2):517-21. DOI: 10.1016/0012-1606(86)90187-9. View

19.

Kanaka-Gantenbein C, Mastorakos G, Chrousos G . Endocrine-related causes and consequences of intrauterine growth retardation. Ann N Y Acad Sci. 2003; 997:150-7. DOI: 10.1196/annals.1290.017. View

20.

Yates 3rd J, Eng J, McCormack A, Schieltz D . Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database. Anal Chem. 1995; 67(8):1426-36. DOI: 10.1021/ac00104a020. View