Alpha 2.0
Login Register
» Articles » PMID: 21240148

Phytochemical and Cytotoxic Investigations of Alpinia Mutica Rhizomes

Overview
Journal Molecules
Publisher MDPI
Specialty Biology
Date 2011 Jan 18
PMID 21240148
Citations 37
Authors
Sri Nurestri Abdul Malek
Chung Weng Phang
Halijah Ibrahim
Abdul Wahab Norhanom
Kae Shin Sim
Affiliations
Soon will be listed here.
Abstract

The methanol and fractionated extracts (hexane, ethyl acetate and water) of Alpinia mutica (Zingiberaceae) rhizomes were investigated for their cytotoxic effect against six human carcinoma cell lines, namely KB, MCF7, A549, Caski, HCT116, HT29 and non-human fibroblast cell line (MRC 5) using an in vitro cytotoxicity assay. The ethyl acetate extract possessed high inhibitory effect against KB, MCF7 and Caski cells (IC₅₀ values of 9.4, 19.7 and 19.8 µg/mL, respectively). Flavokawin B (1), 5,6-dehydrokawain (2), pinostrobin chalcone (3) and alpinetin (4), isolated from the active ethyl acetate extract were also evaluated for their cytotoxic activity. Of these, pinostrobin chalcone (3) and alpinetin (4) were isolated from this plant for the first time. Pinostrobin chalcone (3) displayed very remarkable cytotoxic activity against the tested human cancer cells, such as KB, MCF7 and Caski cells (IC₅₀ values of 6.2, 7.3 and 7.7 µg/mL, respectively). This is the first report of the cytotoxic activity of Alpinia mutica.

Citing Articles

Preparation and Characterization of a Novel Salicin-Cyclodextrin Complex.

Cata A, Ienascu I, Frum A, Ursu D, Svera P, Orha C Pharmaceutics. 2024; 16(3).

PMID: 38543263 PMC: 10976097. DOI: 10.3390/pharmaceutics16030369.

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles.

Hba S, Ghaddar S, Wahnou H, Pinon A, El Kebbaj R, Pouget C Pharmaceutics. 2023; 15(12).

PMID: 38140059 PMC: 10748144. DOI: 10.3390/pharmaceutics15122718.

Natural product-inspired synthesis of coumarin-chalcone hybrids as potential anti-breast cancer agents.

Alhakamy N, Saquib M, Sanobar , Khan M, Ahmad Ansari W, Arif D Front Pharmacol. 2023; 14:1231450.

PMID: 37745072 PMC: 10511752. DOI: 10.3389/fphar.2023.1231450.

Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry.

Rajendran G, Bhanu D, Aruchamy B, Ramani P, Pandurangan N, Bobba K Pharmaceuticals (Basel). 2022; 15(10).

PMID: 36297362 PMC: 9607481. DOI: 10.3390/ph15101250.

A Potential Anticancer Mechanism of Finger Root () Extracts against a Breast Cancer Cell Line.

Widyananda M, Wicaksono S, Rahmawati K, Puspitarini S, Ulfa S, Jatmiko Y Scientifica (Cairo). 2022; 2022:9130252.

PMID: 36106139 PMC: 9467824. DOI: 10.1155/2022/9130252.

References
1.
Mohamad H, Abas F, Permana D, Lajis N, Ali A, Sukari M . DPPH free radical scavenger components from the fruits of Alpinia rafflesiana Wall. ex. Bak. (Zingiberaceae). Z Naturforsch C J Biosci. 2005; 59(11-12):811-5. DOI: 10.1515/znc-2004-11-1208. View
2.
Katerere D, Gray A, Kennedy A, Nash R, Waigh R . Cyclobutanes from Combretum albopunctatum. Phytochemistry. 2004; 65(4):433-8. DOI: 10.1016/j.phytochem.2003.09.014. View
3.
Chang N, Wu C, Wang S, Pei R, Lin C . Alpinia pricei Hayata rhizome extracts have suppressive and preventive potencies against hypercholesterolemia. Food Chem Toxicol. 2010; 48(8-9):2350-6. DOI: 10.1016/j.fct.2010.05.070. View
4.
Kress W, Liu A, Newman M, Li Q . The molecular phylogeny of Alpinia (Zingiberaceae): a complex and polyphyletic genus of gingers. Am J Bot. 2011; 92(1):167-78. DOI: 10.3732/ajb.92.1.167. View
5.
Abdul Malek S, Shin S, Abdul Wahab N, Yaacob H . Cytotoxic components of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Molecules. 2009; 14(5):1713-24. PMC: 6254274. DOI: 10.3390/molecules14051713. View