Peppers: A "Hot" Natural Source for Antitumor Compounds

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Apr 3

PMID 33802144

Citations 6

Authors

Micael Rodrigues Cunha

Mauricio Temotheo Tavares

Thais Batista Fernandes

Roberto Parise-Filho

Affiliations

Soon will be listed here.

Abstract

, , and are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatment with isolated pepper-derived compounds involve mechanisms of cell death, especially through proapoptotic stimuli in tumorigenic cells. In this review, we highlight naturally occurring secondary metabolites of peppers with cytotoxic effects on cancer cell lines. Available mechanisms of cell death, as well as the development of analogues, are also discussed.

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References

Cicero Bezerra Felipe F, Trajano Sousa Filho J, de Oliveira Souza L, Alexandre Silveira J, de Andrade Uchoa D, Silveira E . Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice. Phytomedicine. 2007; 14(9):605-12. DOI: 10.1016/j.phymed.2006.12.015. View

Kumar J, Shankaraiah G, Kumar R, Pitke V, Rao G, Poornima B . Synthesis, anticancer, and antibacterial activities of piplartine derivatives on cell cycle regulation and growth inhibition. J Asian Nat Prod Res. 2013; 15(6):658-69. DOI: 10.1080/10286020.2013.769965. View

Lee J, Lee Y, Ryu H, Kang D, Lee J, Lazar J . Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies. J Comput Aided Mol Des. 2011; 25(4):317-27. PMC: 3420359. DOI: 10.1007/s10822-011-9421-5. View

Lin E, Lin W, Wang S, Chen C, Liao J, Chang H . Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo. J Nutr Biochem. 2011; 23(4):368-78. DOI: 10.1016/j.jnutbio.2011.01.002. View

Fusco B, Giacovazzo M . Peppers and pain. The promise of capsaicin. Drugs. 1997; 53(6):909-14. DOI: 10.2165/00003495-199753060-00001. View

Rali T, Wossa S, Leach D, Waterman P . Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. Molecules. 2007; 12(3):389-94. PMC: 6149483. DOI: 10.3390/12030389. View

Bezerra D, Pessoa C, de Moraes M, Alencar N, Mesquita R, Lima M . In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. J Appl Toxicol. 2007; 28(5):599-607. DOI: 10.1002/jat.1311. View

Yang F, Zheng J . Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. Protein Cell. 2017; 8(3):169-177. PMC: 5326624. DOI: 10.1007/s13238-016-0353-7. View

Sakai T, Eskander R, Guo Y, Kim K, Mefford J, Hopkins J . Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. J Orthop Res. 2012; 30(7):1045-50. PMC: 3685290. DOI: 10.1002/jor.22050. View

10.

Ouyang L, Shi Z, Zhao S, Wang F, Zhou T, Liu B . Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 2012; 45(6):487-98. PMC: 6496669. DOI: 10.1111/j.1365-2184.2012.00845.x. View

11.

Tsai I, Lee F, Wu C, Duh C, Ishikawa T, Chen J . New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens. Planta Med. 2005; 71(6):535-42. DOI: 10.1055/s-2005-864155. View

12.

Zi X, Simoneau A . Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005; 65(8):3479-86. DOI: 10.1158/0008-5472.CAN-04-3803. View

13.

Ji T, Lin C, Krill L, Eskander R, Guo Y, Zi X . Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. Mol Cancer. 2013; 12:55. PMC: 3681603. DOI: 10.1186/1476-4598-12-55. View

14.

Ferreira A, Tavares M, Pasqualoto K, De Azevedo R, Teixeira S, Ferreira-Junior W . RPF151, a novel capsaicin-like analogue: in vitro studies and in vivo preclinical antitumor evaluation in a breast cancer model. Tumour Biol. 2015; 36(9):7251-67. DOI: 10.1007/s13277-015-3441-z. View

15.

Hu J, Feng L, Wang L, Xie Z, Tang Y, Li X . Enantioselective Construction of Cyclobutanes: A New and Concise Approach to the Total Synthesis of (+)-Piperarborenine B. J Am Chem Soc. 2016; 138(40):13151-13154. DOI: 10.1021/jacs.6b08279. View

16.

Newman D, Cragg G . Natural Products as Sources of New Drugs from 1981 to 2014. J Nat Prod. 2016; 79(3):629-61. DOI: 10.1021/acs.jnatprod.5b01055. View

17.

Shoji N, Umeyama A, Saito N, Takemoto T, Kajiwara A, Ohizumi Y . Dehydropipernonaline, an amide possessing coronary vasodilating activity, isolated from Piper longum L. J Pharm Sci. 1986; 75(12):1188-9. DOI: 10.1002/jps.2600751215. View

18.

Lee W, Kim K, Yu S, Kim S, Chun S, Ji J . Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2012; 430(1):406-12. DOI: 10.1016/j.bbrc.2012.11.030. View

19.

Ndebia E, Kamgang R, Nkeh-ChungagAnye B . Analgesic and anti-inflammatory properties of aqueous extract from leaves of Solanum torvum (Solanaceae). Afr J Tradit Complement Altern Med. 2010; 4(2):240-4. PMC: 2816439. DOI: 10.4314/ajtcam.v4i2.31214. View

20.

Gutekunst W, Baran P . Total synthesis and structural revision of the piperarborenines via sequential cyclobutane C-H arylation. J Am Chem Soc. 2011; 133(47):19076-9. PMC: 3223735. DOI: 10.1021/ja209205x. View