Alpinetin Inhibits Breast Cancer Growth by ROS/NF-κB/HIF-1α Axis

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2020 Jun 21

PMID 32562470

Citations 23

Authors

Tao Zhang

Shuai Guo

Xinying Zhu

Jinxia Qiu

Ganzhen Deng

Changwei Qiu

Affiliations

Soon will be listed here.

Abstract

Alpinetin, the main active ingredient in the Chinese medicinal herb Alpinia katsumadai Hayata, has been found to have anticancer activity. However, the therapeutic efficacy of signalling cascades modulated by alpinetin remains unknown. Here, we showed that alpinetin provoked mitochondria-associated apoptosis in a dose-dependent manner in breast cancer cells. Mechanistic investigations revealed that alpinetin dampens hypoxia-inducible factor-1α (HIF-1α) signalling due to a lack of NF-κB activation through reduced mitochondrial reactive oxygen species (ROS) production, decreasing HIF-1α transcription. In vivo, we also found alpinetin led to significant tumour regression by inhibiting NF-κB pathway. Overall, our work uncovers a ROS/NF-κB/HIF-1α axis-dependent mechanism underlying the anticancer effects of alpinetin and suggests that alpinetin could act as a novel therapeutic agent against breast cancer.

Citing Articles

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