From Vaccines to Memory and Back

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2010 Oct 30

PMID 21029957

Citations 346

Authors

Federica Sallusto

Antonio Lanzavecchia

Koichi Araki

Rafi Ahmed

Affiliations

Soon will be listed here.

Abstract

Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells. In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies. Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back.

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