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Class II-independent Generation of CD4 Memory T Cells from Effectors

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Journal Science
Specialty Science
Date 1999 Nov 13
PMID 10558997
Citations 136
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Abstract

The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.

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