P73 Regulates Maintenance of Neural Stem Cell

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2010 Oct 28

PMID 20977890

Citations 49

Authors

Massimiliano Agostini

Paola Tucci

Hailan Chen

Richard A Knight

Daniele Bano

Pierluigi Nicotera

Frank McKeon

Gerry Melino

Affiliations

Soon will be listed here.

Abstract

p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes. In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, together with reduced expression of members of the Sox-2 and Notch gene families known to be important for NSC proliferation. In parallel with this in vitro data, the width of the neurogenic areas was reduced in the brains of embryonic and adult p73-/- mice. These data suggest that p73, and in particular TAp73, is important for maintenance of the NSC pool.

Citing Articles

Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate.

Alonso-Olivares H, Marques M, Prieto-Colomina A, Lopez-Ferreras L, Martinez-Garcia N, Vazquez-Jimenez A Front Cell Dev Biol. 2024; 12:1464932.

PMID: 39376628 PMC: 11456701. DOI: 10.3389/fcell.2024.1464932.

Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment.

Tinnirello R, Chinnici C, Miceli V, Busa R, Bulati M, Gallo A Int J Mol Sci. 2023; 24(17).

PMID: 37686355 PMC: 10487988. DOI: 10.3390/ijms241713550.

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling.

Benjamin D, Both P, Benjamin J, Nutter C, Tan J, Kang J Cell Metab. 2022; 34(6):902-918.e6.

PMID: 35584694 PMC: 9177797. DOI: 10.1016/j.cmet.2022.04.012.

Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation.

Kreimer A, Ashuach T, Inoue F, Khodaverdian A, Deng C, Yosef N Nat Commun. 2022; 13(1):1504.

PMID: 35315433 PMC: 8938438. DOI: 10.1038/s41467-022-28659-0.

TAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin.

Lena A, Foffi E, Agostini M, Mancini M, Annicchiarico-Petruzzelli M, Aberdam D Cell Cycle. 2021; 20(22):2428-2441.

PMID: 34763601 PMC: 8794505. DOI: 10.1080/15384101.2021.1985772.

References

Fujitani M, Cancino G, Dugani C, Weaver I, Gauthier-Fisher A, Paquin A . TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Curr Biol. 2010; 20(22):2058-65. DOI: 10.1016/j.cub.2010.10.029. View

Arsenijevic Y . Mammalian neural stem-cell renewal: nature versus nurture. Mol Neurobiol. 2003; 27(1):73-98. DOI: 10.1385/MN:27:1:73. View

Wang J, Liu Y, Hande M, Wong A, Jin Y, Yin Y . TAp73 is a downstream target of p53 in controlling the cellular defense against stress. J Biol Chem. 2007; 282(40):29152-62. DOI: 10.1074/jbc.M703408200. View

Jensen J, Parmar M . Strengths and limitations of the neurosphere culture system. Mol Neurobiol. 2007; 34(3):153-61. DOI: 10.1385/MN:34:3:153. View

Vousden K, Lane D . p53 in health and disease. Nat Rev Mol Cell Biol. 2007; 8(4):275-83. DOI: 10.1038/nrm2147. View

Muller M, Schilling T, Sayan A, Kairat A, Lorenz K, Schulze-Bergkamen H . TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ. 2005; 12(12):1564-77. DOI: 10.1038/sj.cdd.4401774. View

Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J . p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 2000; 404(6773):99-103. DOI: 10.1038/35003607. View

Melino G, De Laurenzi V, Vousden K . p73: Friend or foe in tumorigenesis. Nat Rev Cancer. 2002; 2(8):605-15. DOI: 10.1038/nrc861. View

Grob T, Novak U, Maisse C, Barcaroli D, Luthi A, Pirnia F . Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001; 8(12):1213-23. DOI: 10.1038/sj.cdd.4400962. View

10.

De Laurenzi V, Raschella G, Barcaroli D, Annicchiarico-Petruzzelli M, Ranalli M, Catani M . Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J Biol Chem. 2000; 275(20):15226-31. DOI: 10.1074/jbc.275.20.15226. View

11.

Yang A, Kaghad M, Caput D, McKeon F . On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 2002; 18(2):90-5. DOI: 10.1016/s0168-9525(02)02595-7. View

12.

Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R . Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010; 24(6):549-60. PMC: 2841333. DOI: 10.1101/gad.1873910. View

13.

Talos F, ABraham A, Vaseva A, Holembowski L, Tsirka S, Scheel A . p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis. Cell Death Differ. 2010; 17(12):1816-29. PMC: 3260880. DOI: 10.1038/cdd.2010.131. View

14.

Kempermann G, Jessberger S, Steiner B, Kronenberg G . Milestones of neuronal development in the adult hippocampus. Trends Neurosci. 2004; 27(8):447-52. DOI: 10.1016/j.tins.2004.05.013. View

15.

Favaro R, Valotta M, Ferri A, Latorre E, Mariani J, Giachino C . Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci. 2009; 12(10):1248-56. DOI: 10.1038/nn.2397. View

16.

Gage F . Mammalian neural stem cells. Science. 2000; 287(5457):1433-8. DOI: 10.1126/science.287.5457.1433. View

17.

Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung C . TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev. 2008; 22(19):2677-91. PMC: 2559903. DOI: 10.1101/gad.1695308. View

18.

Dugani C, Paquin A, Fujitani M, Kaplan D, Miller F . p63 antagonizes p53 to promote the survival of embryonic neural precursor cells. J Neurosci. 2009; 29(20):6710-21. PMC: 6665890. DOI: 10.1523/JNEUROSCI.5878-08.2009. View

19.

Pevny L, Placzek M . SOX genes and neural progenitor identity. Curr Opin Neurobiol. 2005; 15(1):7-13. DOI: 10.1016/j.conb.2005.01.016. View

20.

Billon N, Terrinoni A, Jolicoeur C, McCarthy A, Richardson W, Melino G . Roles for p53 and p73 during oligodendrocyte development. Development. 2004; 131(6):1211-20. DOI: 10.1242/dev.01035. View