TAp63 Regulates Bone Remodeling by Modulating the Expression of TNFRSF11B/Osteoprotegerin

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2021 Nov 12

PMID 34763601

Authors

Anna Maria Lena

Erica Foffi

Massimiliano Agostini

Mara Mancini

Margherita Annicchiarico-Petruzzelli

Daniel Aberdam

Tania Velletri

Yufang Shi

Gerry Melino

Ying Wang

Eleonora Candi

Affiliations

Soon will be listed here.

Abstract

MSC, mesenchymal stem cells; OPG, osteoprotegerin; RUNX2, Run-trelated transcription factor 2.

Citing Articles

Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment.

Gerini G, Traversa A, Cece F, Cassandri M, Pontecorvi P, Camero S Cells. 2025; 14(2).

PMID: 39851564 PMC: 11763738. DOI: 10.3390/cells14020135.

References

Sisay M, Mengistu G, Edessa D . The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy. Onco Targets Ther. 2017; 10:3801-3810. PMC: 5538694. DOI: 10.2147/OTT.S135867. View

Lung D, Reese R, Alarid E . Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1. Horm Cancer. 2020; 11(3-4):129-147. PMC: 7384552. DOI: 10.1007/s12672-020-00388-0. View

Su X, Napoli M, Abbas H, Venkatanarayan A, Bui N, Coarfa C . TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway. Oncogene. 2016; 36(17):2377-2393. PMC: 5415945. DOI: 10.1038/onc.2016.388. View

Li R, Teng X, Zhu H, Han T, Liu Q . MiR-4500 Regulates PLXNC1 and Inhibits Papillary Thyroid Cancer Progression. Horm Cancer. 2019; 10(4-6):150-160. PMC: 10355716. DOI: 10.1007/s12672-019-00366-1. View

Napoli M, Flores E . The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy. Br J Cancer. 2016; 116(2):149-155. PMC: 5243983. DOI: 10.1038/bjc.2016.384. View

Brown J, Zhang J, Keller E . Opg, RANKl, and RANK in cancer metastasis: expression and regulation. Cancer Treat Res. 2004; 118:149-72. DOI: 10.1007/978-1-4419-9129-4_7. View

Lorona N, Cook L, Tang M, Hill D, Wiggins C, Li C . Recent Use of Oral Contraceptives and Risk of Luminal B, Triple-Negative, and HER2-Overexpressing Breast Cancer. Horm Cancer. 2019; 10(2-3):71-76. PMC: 6550997. DOI: 10.1007/s12672-019-00362-5. View

Bolf E, Gillis N, Barnum M, Beaudet C, Yu G, Tomczak J . The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. Horm Cancer. 2019; 11(1):34-41. PMC: 8007220. DOI: 10.1007/s12672-019-00373-2. View

Agostini M, Niklison-Chirou M, Annicchiarico-Petruzzelli M, Grelli S, Di Daniele N, Pestlikis I . p73 Regulates Primary Cortical Neuron Metabolism: a Global Metabolic Profile. Mol Neurobiol. 2017; 55(4):3237-3250. DOI: 10.1007/s12035-017-0517-3. View

10.

Weichhaus M, Chung S, Connelly L . Osteoprotegerin in breast cancer: beyond bone remodeling. Mol Cancer. 2015; 14:117. PMC: 4460694. DOI: 10.1186/s12943-015-0390-5. View

11.

Kong Y, Yoshida H, Sarosi I, Tan H, Timms E, Capparelli C . OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999; 397(6717):315-23. DOI: 10.1038/16852. View

12.

Bucay N, Sarosi I, Dunstan C, Morony S, Tarpley J, Capparelli C . osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998; 12(9):1260-8. PMC: 316769. DOI: 10.1101/gad.12.9.1260. View

13.

Agostini M, Tucci P, Killick R, Candi E, Sayan B, Rivetti di Val Cervo P . Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A. 2011; 108(52):21093-8. PMC: 3248477. DOI: 10.1073/pnas.1112061109. View

14.

Wang X, Kua H, Hu Y, Guo K, Zeng Q, Wu Q . p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol. 2005; 172(1):115-25. PMC: 2063539. DOI: 10.1083/jcb.200507106. View

15.

Su X, Paris M, Gi Y, Tsai K, Cho M, Lin Y . TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell. 2009; 5(1):64-75. PMC: 3418222. DOI: 10.1016/j.stem.2009.04.003. View

16.

Simonet W, Lacey D, Dunstan C, Kelley M, Chang M, Luthy R . Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997; 89(2):309-19. DOI: 10.1016/s0092-8674(00)80209-3. View

17.

Behzatoglu K . Osteoclasts in Tumor Biology: Metastasis and Epithelial-Mesenchymal-Myeloid Transition. Pathol Oncol Res. 2021; 27:609472. PMC: 8262221. DOI: 10.3389/pore.2021.609472. View

18.

Infante M, Fabi A, Cognetti F, Gorini S, Caprio M, Fabbri A . RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives. J Exp Clin Cancer Res. 2019; 38(1):12. PMC: 6325760. DOI: 10.1186/s13046-018-1001-2. View

19.

Chakrabarti R, Wei Y, Hwang J, Hang X, Blanco M, Choudhury A . ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol. 2014; 16(10):1004-15, 1-13. PMC: 4183725. DOI: 10.1038/ncb3040. View

20.

Nemajerova A, Amelio I, Gebel J, Dotsch V, Melino G, Moll U . Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism. Cell Death Differ. 2017; 25(1):144-153. PMC: 5729534. DOI: 10.1038/cdd.2017.178. View