The Nuclear Pore Complex: Bridging Nuclear Transport and Gene Regulation

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2010 Jun 24

PMID 20571586

Citations 297

Authors

Caterina Strambio-De-Castillia

Mario Niepel

Michael P Rout

Affiliations

Soon will be listed here.

Abstract

Although the nuclear pore complex (NPC) is best known for its primary function as the key regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of experimental evidence suggests that this structure participates in a considerably broader range of cellular activities on both sides of the nuclear envelope. Indeed, the NPC is emerging as an important regulator of gene expression through its influence on the internal architectural organization of the nucleus and its apparently extensive involvement in coordinating the seamless delivery of genetic information to the cytoplasmic protein synthesis machinery.

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