GammadeltaTCR Ligands and Lineage Commitment

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2010 May 8

PMID 20447836

Citations 13

Authors

Taras Kreslavsky

Harald von Boehmer

Affiliations

Soon will be listed here.

Abstract

Two major T lymphocyte lineages--alphabeta and gammadelta T cells--develop in the thymus from common precursors. Differentiation of both lineages requires signals coming from TCRs. Development of alphabeta T cells is driven at early stages by signaling from the pre-TCR, most likely in a ligand-independent fashion, and later--by signals delivered by alphabetaTCRs binding to their ligands--classical or non-classical MHC molecules. gammadelta lineage cells likewise require TCR signaling for their differentiation. Recent work from several groups suggests that TCR signaling not only ensures the developmental progression towards alphabeta and gammadelta lineages but that signal strength instructs lineage fate: weaker TCR signal results in alphabeta and stronger--in gammadelta lineage commitment. However, as most gammadeltaTCRs remain orphan receptors, it is still debated whether strong signals from gammadeltaTCRs in development are generated in a ligand-dependent manner (as in the case of alphabetaTCRs), ligand-independent manner (as for pre-TCR) or both. Here we summarize evidence supporting a possible role for ligands in gammadelta T cell lineage commitment and the generation of gammadelta sublineages.

Citing Articles

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References

Bonneville M, Scotet E . Human Vgamma9Vdelta2 T cells: promising new leads for immunotherapy of infections and tumors. Curr Opin Immunol. 2006; 18(5):539-46. DOI: 10.1016/j.coi.2006.07.002. View

Grigoriadou K, Boucontet L, Pereira P . Most IL-4-producing gamma delta thymocytes of adult mice originate from fetal precursors. J Immunol. 2003; 171(5):2413-20. DOI: 10.4049/jimmunol.171.5.2413. View

Xiong N, Kang C, Raulet D . Positive selection of dendritic epidermal gammadelta T cell precursors in the fetal thymus determines expression of skin-homing receptors. Immunity. 2004; 21(1):121-31. DOI: 10.1016/j.immuni.2004.06.008. View

French J, Roark C, Born W, OBrien R . {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A. 2005; 102(41):14741-6. PMC: 1239947. DOI: 10.1073/pnas.0507520102. View

OBRIEN R, Happ M, Dallas A, Palmer E, Kubo R, Born W . Stimulation of a major subset of lymphocytes expressing T cell receptor gamma delta by an antigen derived from Mycobacterium tuberculosis. Cell. 1989; 57(4):667-74. DOI: 10.1016/0092-8674(89)90135-9. View

Buch T, Rieux-Laucat F, Forster I, Rajewsky K . Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity. 2002; 16(5):707-18. DOI: 10.1016/s1074-7613(02)00312-6. View

Born W, Vollmer M, Reardon C, Matsuura E, Voelker D, Giclas P . Hybridomas expressing gammadelta T-cell receptors respond to cardiolipin and beta2-glycoprotein 1 (apolipoprotein H). Scand J Immunol. 2003; 58(3):374-81. DOI: 10.1046/j.1365-3083.2003.01315.x. View

Lauritsen J, Wong G, Lee S, Lefebvre J, Ciofani M, Rhodes M . Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009; 31(4):565-75. PMC: 2768560. DOI: 10.1016/j.immuni.2009.07.010. View

Vidovic D, Roglic M, McKune K, Guerder S, MacKay C, Dembic Z . Qa-1 restricted recognition of foreign antigen by a gamma delta T-cell hybridoma. Nature. 1989; 340(6235):646-50. DOI: 10.1038/340646a0. View

10.

Aifantis I, Bassing C, Garbe A, Sawai K, Alt F, von Boehmer H . The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med. 2006; 203(6):1543-50. PMC: 2118313. DOI: 10.1084/jem.20051711. View

11.

Correa I, Bix M, Liao N, Zijlstra M, Jaenisch R, Raulet D . Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice. Proc Natl Acad Sci U S A. 1992; 89(2):653-7. PMC: 48297. DOI: 10.1073/pnas.89.2.653. View

12.

von Boehmer H . Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development. Adv Immunol. 2004; 84:201-38. DOI: 10.1016/S0065-2776(04)84006-9. View

13.

Davis M, Bjorkman P . T-cell antigen receptor genes and T-cell recognition. Nature. 1988; 334(6181):395-402. DOI: 10.1038/334395a0. View

14.

Weng A, Ferrando A, Lee W, Morris 4th J, Silverman L, Sanchez-Irizarry C . Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004; 306(5694):269-71. DOI: 10.1126/science.1102160. View

15.

Meyer C, Zeng X, Chien Y . Ligand recognition during thymic development and gammadelta T cell function specification. Semin Immunol. 2010; 22(4):207-13. PMC: 2906674. DOI: 10.1016/j.smim.2010.04.002. View

16.

Adams E, Strop P, Shin S, Chien Y, Garcia K . An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat Immunol. 2008; 9(7):777-84. PMC: 2768525. DOI: 10.1038/ni.1620. View

17.

Heilig J, Tonegawa S . Diversity of murine gamma genes and expression in fetal and adult T lymphocytes. Nature. 1986; 322(6082):836-40. DOI: 10.1038/322836a0. View

18.

Weiner D, Liu J, Cohen J, Williams W, Greene M . A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature. 1989; 339(6221):230-1. DOI: 10.1038/339230a0. View

19.

Roberts K, Yokoyama W, Kehn P, Shevach E . The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells. J Exp Med. 1991; 173(1):231-40. PMC: 2118771. DOI: 10.1084/jem.173.1.231. View

20.

Scotet E, Martinez L, Grant E, Barbaras R, Jeno P, Guiraud M . Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity. 2005; 22(1):71-80. DOI: 10.1016/j.immuni.2004.11.012. View