Notch Signaling in T-Cell Development and T-ALL

Overview

Journal ISRN Hematol

Specialty Hematology

Date 2011 Nov 24

PMID 22111016

Citations 13

Authors

Xiaoyu Li

Harald von Boehmer

Affiliations

Soon will be listed here.

Abstract

The Notch signaling pathway is an evolutionarily conserved cell signaling system present in most multicellular organisms, as it controls cell fate specification by regulating cell proliferation, differentiation, apoptosis, and survival. Regulation of the Notch signaling pathway can be achieved at multiple levels. Notch proteins are involved in lineage fate decisions in a variety of tissues in various species. Notch is essential for T lineage cell differentiation including T versus B and αβ versus γδ lineage specification. In this paper, we discuss Notch signaling in normal T-cell maturation and differentiation as well as in T-cell acute lymphoblastic lymphoma/leukemia.

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