Regulation of Alternative Splicing by Histone Modifications

Overview

Journal Science

Specialty Science

Date 2010 Feb 6

PMID 20133523

Citations 609

Authors

Reini F Luco

Qun Pan

Kaoru Tominaga

Benjamin J Blencowe

Olivia M Pereira-Smith

Tom Misteli

Affiliations

Soon will be listed here.

Abstract

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.

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