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Tom Misteli

Explore the profile of Tom Misteli including associated specialties, affiliations and a list of published articles. Areas
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Articles 231
Citations 18404
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Recent Articles
1.
Sood V, Holewinski R, Andresson T, Larson D, Misteli T
Mol Cell . 2025 Feb; 85(5):913-928.e8. PMID: 39978338
Stochastic transcriptional bursting is a universal property of active genes. While different genes exhibit distinct bursting patterns, the molecular mechanisms that govern gene-specific stochastic bursting are largely unknown. We have...
2.
Keikhosravi A, Guin K, Pegoraro G, Misteli T
bioRxiv . 2025 Feb; PMID: 39896519
A prominent feature of eukaryotic chromosomes are centromeres, which are specialized regions of repetitive DNA required for faithful chromosome segregation during cell division. In interphase cells centromeres are non-randomly positioned...
3.
Keikhosravi A, Almansour F, Bohrer C, Fursova N, Guin K, Sood V, et al.
Sci Rep . 2024 Aug; 14(1):18426. PMID: 39117696
High-throughput imaging (HTI) generates complex imaging datasets from a large number of experimental perturbations. Commercial HTI software programs for image analysis workflows typically do not allow full customization and adoption...
4.
Sood V, Holewinski R, Andresson T, Larson D, Misteli T
bioRxiv . 2024 Jun; PMID: 38903099
Stochastic transcriptional bursting is a universal property of active genes. While different genes exhibit distinct bursting patterns, the molecular mechanisms for gene-specific stochastic bursting are largely unknown. We have developed...
5.
Misteli T
Histochem Cell Biol . 2024 Jun; 162(1-2):1-2. PMID: 38850309
No abstract available.
6.
Almansour F, Keikhosravi A, Pegoraro G, Misteli T
Histochem Cell Biol . 2024 May; 162(1-2):65-77. PMID: 38724854
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with implications for gene expression and regulation. While all genome organization features,...
7.
Mian Y, Wang L, Keikhosravi A, Guo K, Misteli T, Arda H, et al.
Mol Biol Cell . 2024 May; 35(7):ar96. PMID: 38717453
Cell type-specific enhancers are critically important for lineage specification. The mechanisms that determine cell-type specificity of enhancer activity, however, are not fully understood. Most current models for how enhancers function...
8.
Almansour F, Keikhosravi A, Pegoraro G, Misteli T
bioRxiv . 2024 Mar; PMID: 38529487
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with implications for gene expression and regulation. While all genome organization features,...
9.
Shilo A, Pegoraro G, Misteli T
Methods Mol Biol . 2024 Mar; 2784:133-146. PMID: 38502483
RNA-fluorescence in situ hybridization (RNA-FISH) is an essential and widely used tool for visualizing RNA molecules in intact cells. Recent advances have increased RNA-FISH sensitivity, signal detection efficiency, and throughput....
10.
Almansour F, Keikhosravi A, Pegoraro G, Misteli T
Res Sq . 2024 Mar; PMID: 38464289
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with implications for gene expression and regulation. While all genome organization features,...