The Major Histocompatibility Complex Class II-linked Cim Locus Controls the Kinetics of Intracellular Transport of a Classical Class I Molecule

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1991 Apr 1

PMID 2007857

Citations 14

Authors

S J Powis

J C Howard

G W Butcher

Affiliations

Soon will be listed here.

Abstract

The dominant trans-acting major histocompatibility complex (MHC)-linked class I modifier (cim) locus, previously recognized through its ability to determine altered alloantigenicity of a rat class I molecule, RT1.A3, is shown here to influence class I intracellular transport. The MHC recombinant laboratory rat strains PVG.R1 and PVG.R8 display unusually long retention of RT1.Aa within the endoplasmic reticulum or cis-Golgi. In appropriate F1 hybrid cells heterozygous for RT1.Aa and another class I MHC allele, RT1.Ac, only the RT1.Aa protein is subject to slow transport. The cim gene product therefore shows class I allele specificity in its action, cim appears to be a polymorphic locus whose product is directly involved in the processes of class I MHC assembly and/or intracellular transport.

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