Circulating Tumor Cells: a Window into Cancer Biology and Metastasis

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 2010 Jan 15

PMID 20071161

Citations 147

Authors

Shyamala Maheswaran

Daniel A Haber

Affiliations

Soon will be listed here.

Abstract

The presence of circulating tumor cells (CTCs) accompanies tumor invasion into the bloodstream. Detection, monitoring, and molecular analysis of these rare cancer cells shed into blood will provide a powerful and noninvasive approach for the detection of early disease, assessing prognosis and therapeutic response in established cancers, and targeting metastatic precursor cells. We review current and emerging technologies for CTC isolation, with a focus on capture efficiency, purity, and viability of CTCs, and their potential clinical applications.

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