Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics

Overview

Journal Nutrients

Date 2023 Jul 11

PMID 37432240

Authors

Pratibha Pandey

Fahad Khan

Sara A Seifeldin

Khalid Alshaghdali

Samra Siddiqui

Mohamed Elfatih Abdelwadoud

Manish Vyas

Mohd Saeed

Avijit Mazumder

Amir Saeed

Affiliations

Soon will be listed here.

Abstract

The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members of the Wnt pathway have been proven to be effective biomarkers and promising cancer therapeutic targets. Abnormal stimulation of the Wnt signaling pathway has been linked to the initiation and advancement of cancer in both clinical research and in vitro investigations. A reduction in cancer incidence rate and an improvement in survival may result from targeting the Wnt/β-catenin pathway. As a result, blocking this pathway has been the focus of cancer research, and several candidates that can be targeted are currently being developed. Flavonoids derived from plants exhibit growth inhibitory, apoptotic, anti-angiogenic, and anti-migratory effects against various malignancies. Moreover, flavonoids influence different signaling pathways, including Wnt, to exert their anticancer effects. In this review, we comprehensively evaluate the influence of flavonoids on cancer development and metastasis by focusing on the Wnt/β-catenin signaling pathway, and we provide evidence of their impact on a number of molecular targets. Overall, this review will enhance our understanding of these natural products as Wnt pathway modulators.

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