Recent Concepts for the Roles of Progenitor/stem Cell Niche in Heart Repair

Overview

Journal Am J Cardiovasc Dis

Specialty Cardiology & Vascular Diseases

Date 2012 Jan 19

PMID 22254217

Citations 4

Authors

Yuliang Feng

Xi-Yong Yu

Yigang Wang

Affiliations

Soon will be listed here.

Abstract

Progenitor/stem cell (PSC) has shown great promise for generation in failing heart. Advances in PSC biology have greatly enhanced our understanding of how PSC self-renewal, migration, maintenance of stemness, and cell-fate commitment depend on the balance of complex signals in their microenvironment. Endogenous PSC exists within structural and functional units known as PSC niches, which play important roles in directing PSC behavior. Recent years have witnessed great progress in our understanding of the PSC niche in cardiovascular biology. PSC based therapy could lead to successful cardiac regeneration or repair. Realizing the potential of therapeutic strategies is based on 1) differentiation of the PSC into all of the cellular constituents of the heart; 2) release of paracrine/ autocrine factors from the PSC; 3) fusion of the PSC with the existing constituents of the heart; and 4) stimulation of endogenous repair (regeneration of PSC niches). Importantly, cardiac PSC niches contain supporting cells and these cell-cell interactions have crucial regulatory roles in PSC based therapy. These findings have important implications for heart development, bioengineering, and furthermore elucidate a broader dimension of PSC control within the niche toward cardiomyocyte phenotype.

Citing Articles

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References

Smith-Berdan S, Nguyen A, Hassanein D, Zimmer M, Ugarte F, Ciriza J . Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches. Cell Stem Cell. 2011; 8(1):72-83. PMC: 3625377. DOI: 10.1016/j.stem.2010.11.030. View

Behfar A, Zingman L, Hodgson D, Rauzier J, Kane G, Terzic A . Stem cell differentiation requires a paracrine pathway in the heart. FASEB J. 2002; 16(12):1558-66. DOI: 10.1096/fj.02-0072com. View

Wang Y, Zhang D, Ashraf M, Zhao T, Huang W, Ashraf A . Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2009; 298(1):H275-86. PMC: 2806133. DOI: 10.1152/ajpheart.00765.2009. View

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

Yin Y, Huang L, Zhao X, Fang Y, Yu S, Zhao J . AMD3100 mobilizes endothelial progenitor cells in mice, but inhibits its biological functions by blocking an autocrine/paracrine regulatory loop of stromal cell derived factor-1 in vitro. J Cardiovasc Pharmacol. 2007; 50(1):61-7. DOI: 10.1097/FJC.0b013e3180587e4d. View

Shi M, Li J, Liao L, Chen B, Li B, Chen L . Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica. 2007; 92(7):897-904. DOI: 10.3324/haematol.10669. View

Soldner F, Hockemeyer D, Beard C, Gao Q, Bell G, Cook E . Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009; 136(5):964-77. PMC: 2787236. DOI: 10.1016/j.cell.2009.02.013. View

Woltjen K, Michael I, Mohseni P, Desai R, Mileikovsky M, Hamalainen R . piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009; 458(7239):766-70. PMC: 3758996. DOI: 10.1038/nature07863. View

Wilson A, Trumpp A . Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006; 6(2):93-106. DOI: 10.1038/nri1779. View

10.

Wynn R, Hart C, Corradi-Perini C, ONeill L, Evans C, Wraith J . A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood. 2004; 104(9):2643-5. DOI: 10.1182/blood-2004-02-0526. View

11.

Zhang D, Huang W, Dai B, Zhao T, Ashraf A, Millard R . Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts. Am J Physiol Heart Circ Physiol. 2010; 299(5):H1339-47. PMC: 2993193. DOI: 10.1152/ajpheart.00592.2010. View

12.

Gersh B, Simari R, Behfar A, Terzic C, Terzic A . Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc. 2009; 84(10):876-92. PMC: 2755807. DOI: 10.4065/84.10.876. View

13.

Covello K, Kehler J, Yu H, Gordan J, Arsham A, Hu C . HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006; 20(5):557-70. PMC: 1410808. DOI: 10.1101/gad.1399906. View

14.

Narazaki G, Uosaki H, Teranishi M, Okita K, Kim B, Matsuoka S . Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation. 2008; 118(5):498-506. DOI: 10.1161/CIRCULATIONAHA.108.769562. View

15.

Wang J, He H, Yu L, Hua-Xiang Xia H, Lin M, Gu Q . HSF1 down-regulates XAF1 through transcriptional regulation. J Biol Chem. 2005; 281(5):2451-9. DOI: 10.1074/jbc.M505890200. View

16.

Urbanek K, Cesselli D, Rota M, Nascimbene A, De Angelis A, Hosoda T . Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A. 2006; 103(24):9226-31. PMC: 1474010. DOI: 10.1073/pnas.0600635103. View

17.

Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin I . Human induced pluripotent stem cells free of vector and transgene sequences. Science. 2009; 324(5928):797-801. PMC: 2758053. DOI: 10.1126/science.1172482. View

18.

Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S . Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell. 2009; 5(3):237-41. DOI: 10.1016/j.stem.2009.08.001. View

19.

Zaruba M, Theiss H, Vallaster M, Mehl U, Brunner S, David R . Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell. 2009; 4(4):313-23. DOI: 10.1016/j.stem.2009.02.013. View

20.

Lapidot T, Petit I . Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol. 2002; 30(9):973-81. DOI: 10.1016/s0301-472x(02)00883-4. View