Square Pyramidal Copper(II) Complexes with Forth Generation Fluoroquinolone and Neutral Bidentate Ligand: Structure, Antibacterial, SOD Mimic and DNA-interaction Studies

Overview

Journal Bioorg Med Chem

Specialties Biochemistry
Chemistry

Date 2010 Jan 5

PMID 20045652

Citations 7

Authors

Mohan N Patel

Pradhuman A Parmar

Deepen S Gandhi

Affiliations

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Abstract

Coordination of neutral bidentate ligand to copper ion in combination with gatifloxacin have been focused in this article. The effect of complexation reflects antibacterial activity, DNA interaction and SOD mimic activity of individual greatly. The geometry at the central metal ion provides a site for binding of superoxide anion responsible for better SOD mimic behaviour.

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