Meta-analyses of Genome-wide Association Studies Identify Multiple Loci Associated with Pulmonary Function

Overview

Journal Nat Genet

Specialty Genetics

Date 2009 Dec 17

PMID 20010835

Citations 340

Authors

Dana B Hancock

Mark Eijgelsheim

Jemma B Wilk

Sina A Gharib

Laura R Loehr

Kristin D Marciante

Nora Franceschini

Yannick M T A van Durme

Ting-Hsu Chen

R Graham Barr

Matthew B Schabath

David J Couper

Guy G Brusselle

Bruce M Psaty

Cornelia M Van Duijn

Jerome I Rotter

Andre G Uitterlinden

Albert Hofman

Naresh M Punjabi

Fernando Rivadeneira

Alanna C Morrison

Paul L Enright

Kari E North

Susan R Heckbert

Thomas Lumley

Bruno H C Stricker

George T OConnor

Stephanie J London

Affiliations

Soon will be listed here.

Abstract

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

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