How Couples Who Have Undergone in Vitro Fertilization Decide What to Do with Surplus Frozen Embryos

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2009 Aug 25

PMID 19700150

Citations 16

Authors

Robert D Nachtigall

Kirstin Mac Dougall

Jennifer Harrington

Julia Duff

Matthew Lee

Gay Becker

Affiliations

Soon will be listed here.

Abstract

In a qualitative interview study of 77 families with stored frozen embryos, we found that while embryo disposition decision making was influenced by individual life circumstances, embryo quantity/quality, personal values, embryo conceptualization, and clinic information, it was a stepwise process that could be represented as three sequential questions: (1) Will the embryos be used for additional attempts at conception? If not, (2) Will the embryos remain in storage? And if not, (3) Will the embryos be donated to other people or to science, or will they be destroyed? While almost two-thirds (63%) of participants kept their embryos in storage after 5 years, either passively through disagreement or indecision or actively to maintain embryo potential, avert feelings of loss, or as psychological or genetic "insurance," IVF clinic support and detailed information about options motivated families to make disposition decisions.

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References

Fuscaldo G, Russell S, Gillam L . How to facilitate decisions about surplus embryos: patients' views. Hum Reprod. 2007; 22(12):3129-38. DOI: 10.1093/humrep/dem325. View

Hammarberg K, Tinney L . Deciding the fate of supernumerary frozen embryos: a survey of couples' decisions and the factors influencing their choice. Fertil Steril. 2006; 86(1):86-91. DOI: 10.1016/j.fertnstert.2005.11.071. View

de Lacey S . Parent identity and 'virtual' children: why patients discard rather than donate unused embryos. Hum Reprod. 2005; 20(6):1661-9. DOI: 10.1093/humrep/deh831. View

Bangsboll S, Pinborg A, Andersen C, Nyboe Andersen A . Patients' attitudes towards donation of surplus cryopreserved embryos for treatment or research. Hum Reprod. 2004; 19(10):2415-9. DOI: 10.1093/humrep/deh441. View

de Lacey S . Decisions for the fate of frozen embryos: fresh insights into patients' thinking and their rationales for donating or discarding embryos. Hum Reprod. 2007; 22(6):1751-8. DOI: 10.1093/humrep/dem056. View

Lyerly A, Steinhauser K, Voils C, Namey E, Alexander C, Bankowski B . Fertility patients' views about frozen embryo disposition: results of a multi-institutional U.S. survey. Fertil Steril. 2008; 93(2):499-509. PMC: 2828821. DOI: 10.1016/j.fertnstert.2008.10.015. View

de Lacey S . Patients' attitudes to their embryos and their destiny: social conditioning?. Best Pract Res Clin Obstet Gynaecol. 2006; 21(1):101-12. DOI: 10.1016/j.bpobgyn.2006.08.003. View

Parry S . (Re)constructing embryos in stem cell research: exploring the meaning of embryos for people involved in fertility treatments. Soc Sci Med. 2005; 62(10):2349-59. DOI: 10.1016/j.socscimed.2005.10.024. View

Van Voorhis B, Grinstead D, Sparks A, Gerard J, Weir R . Establishment of a successful donor embryo program: medical, ethical, and policy issues. Fertil Steril. 1999; 71(4):604-8. DOI: 10.1016/s0015-0282(98)00545-7. View

10.

Kingsberg S, Applegarth L, Janata J . Embryo donation programs and policies in North America: survey results and implications for health and mental health professionals. Fertil Steril. 2000; 73(2):215-20. DOI: 10.1016/s0015-0282(99)00506-3. View

11.

Laruelle C, Englert Y . Psychological study of in vitro fertilization-embryo transfer participants' attitudes toward the destiny of their supernumerary embryos. Fertil Steril. 1995; 63(5):1047-50. DOI: 10.1016/s0015-0282(16)57546-3. View

12.

McMahon C, Gibson F, Leslie G, Saunders D, Porter K, Tennant C . Embryo donation for medical research: attitudes and concerns of potential donors. Hum Reprod. 2003; 18(4):871-7. DOI: 10.1093/humrep/deg167. View

13.

Nachtigall R, Becker G, Friese C, Butler A, MacDougall K . Parents' conceptualization of their frozen embryos complicates the disposition decision. Fertil Steril. 2005; 84(2):431-4. PMC: 2811165. DOI: 10.1016/j.fertnstert.2005.01.134. View

14.

Darlington N, Matson P . The fate of cryopreserved human embryos approaching their legal limit of storage within a West Australian in-vitro fertilization clinic. Hum Reprod. 1999; 14(9):2343-4. DOI: 10.1093/humrep/14.9.2343. View

15.

Lyerly A, Faden R . Embryonic stem cells. Willingness to donate frozen embryos for stem cell research. Science. 2007; 317(5834):46-7. DOI: 10.1126/science.1145067. View

16.

Lyerly A, Steinhauser K, Namey E, Tulsky J, Cook-Deegan R, Sugarman J . Factors that affect infertility patients' decisions about disposition of frozen embryos. Fertil Steril. 2006; 85(6):1623-30. DOI: 10.1016/j.fertnstert.2005.11.056. View

17.

Zweifel J, Rathert M, Klock S, Walaski H, Pritts E, Olive D . Comparative assessment of pre- and post-donation attitudes towards potential oocyte and embryo disposition and management among ovum donors in an oocyte donation programme. Hum Reprod. 2006; 21(5):1325-7. DOI: 10.1093/humrep/dei468. View

18.

Newton C, McDermid A, Tekpetey F, Tummon I . Embryo donation: attitudes toward donation procedures and factors predicting willingness to donate. Hum Reprod. 2003; 18(4):878-84. DOI: 10.1093/humrep/deg169. View

19.

Burton P, Sanders K . Patient attitudes to donation of embryos for research in Western Australia. Med J Aust. 2004; 180(11):559-61. DOI: 10.5694/j.1326-5377.2004.tb06091.x. View

20.

McMahon C, Saunders D . Attitudes of couples with stored frozen embryos toward conditional embryo donation. Fertil Steril. 2007; 91(1):140-7. DOI: 10.1016/j.fertnstert.2007.08.004. View