Redox-sensitive Cysteines Bridge P300/CBP-mediated Acetylation and FoxO4 Activity

Overview

Journal Nat Chem Biol

Specialties Biochemistry
Biology
Chemistry

Date 2009 Aug 4

PMID 19648934

Citations 101

Authors

Tobias B Dansen

Lydia M M Smits

Miranda H van Triest

Peter L J de Keizer

Dik van Leenen

Marian Groot Koerkamp

Anna Szypowska

Amanda Meppelink

Arjan B Brenkman

Junji Yodoi

Frank C P Holstege

Boudewijn M T Burgering

Affiliations

Soon will be listed here.

Abstract

Cellular damage invoked by reactive oxygen species plays a key role in the pathobiology of cancer and aging. Forkhead box class O (FoxO) transcription factors are involved in various cellular processes including cell cycle regulation, apoptosis and resistance to reactive oxygen species, and studies in animal models have shown that these transcription factors are of vital importance in tumor suppression, stem cell maintenance and lifespan extension. Here we report that the activity of FoxO in human cells is directly regulated by the cellular redox state through a unique mechanism in signal transduction. We show that reactive oxygen species induce the formation of cysteine-thiol disulfide-dependent complexes of FoxO and the p300/CBP acetyltransferase, and that modulation of FoxO biological activity by p300/CBP-mediated acetylation is fully dependent on the formation of this redox-dependent complex. These findings directly link cellular redox status to the activity of the longevity protein FoxO.

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