Boudewijn M T Burgering
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Explore the profile of Boudewijn M T Burgering including associated specialties, affiliations and a list of published articles.
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82
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5868
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Recent Articles
1.
Nguyen N, Gevers S, Kok R, Burgering L, Neikes H, Akkerman N, et al.
Cell Metab
. 2025 Feb;
PMID: 39933514
Tumors arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumors, however, retain some hierarchical organization, maintaining both cancer stem cells...
2.
Zelina P, de Ruiter A, Kolsteeg C, van Ginneken I, Vos H, Supiot L, et al.
Acta Neuropathol Commun
. 2024 Sep;
12(1):144.
PMID: 39227882
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease leading to motor neuron loss. Currently mutations in > 40 genes have been linked to ALS, but the contribution of many...
3.
van Soest D, Polderman P, den Toom W, Keijer J, van Roosmalen M, Leyten T, et al.
Nat Commun
. 2024 Mar;
15(1):2725.
PMID: 38548751
Reactive Oxygen Species (ROS) derived from mitochondrial respiration are frequently cited as a major source of chromosomal DNA mutations that contribute to cancer development and aging. However, experimental evidence showing...
4.
Gui T, Fleming C, Manzato C, Bourgeois B, Sirati N, Heuer J, et al.
Mol Cell
. 2023 Nov;
83(22):4141-4157.e11.
PMID: 37977121
Biomolecular condensates have emerged as a major organizational principle in the cell. However, the formation, maintenance, and dissolution of condensates are still poorly understood. Transcriptional machinery partitions into biomolecular condensates...
5.
Rodriguez-Colman M, Dansen T, Burgering B
Nat Rev Mol Cell Biol
. 2023 Sep;
25(1):46-64.
PMID: 37710009
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16, which gained notoriety for its capability to...
6.
den Toom W, van Soest D, Polderman P, van Triest M, Bruurs L, De Henau S, et al.
Free Radic Biol Med
. 2023 Jul;
206:134-142.
PMID: 37392950
Reactive Oxygen Species (ROS) in the form of HO can act both as physiological signaling molecules as well as damaging agents, depending on their concentration and localization. The downstream biological...
7.
Mocholi E, Russo L, Gopal K, Ramstead A, Hochrein S, Vos H, et al.
Cell Rep
. 2023 Jun;
42(6):112583.
PMID: 37267106
Upon antigen-specific T cell receptor (TCR) engagement, human CD4 T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that the generation...
8.
Ludikhuize M, Gevers S, Nguyen N, Meerlo M, Roudbari S, Gulersonmez M, et al.
Commun Biol
. 2022 Nov;
5(1):1159.
PMID: 36316440
Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are...
9.
Bui T, Burgering B, Goga A, Rugo H, J van t Veer L
JCO Precis Oncol
. 2022 Jun;
6:e2100473.
PMID: 35666959
Purpose: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have emerged as effective treatments for patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced/metastatic breast cancer (mBC). Dedicated research efforts...
10.
Tavares S, Liv N, Pasolli M, Opdam M, Ratze M, Saornil M, et al.
Cell Rep
. 2022 Apr;
39(1):110584.
PMID: 35385742
Elevated expression of non-receptor tyrosine kinase FER is an independent prognosticator that correlates with poor survival of high-grade and basal/triple-negative breast cancer (TNBC) patients. Here, we show that high FER...