Role of Dicer in Female Fertility

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2009 Aug 4

PMID 19646895

Citations 27

Authors

Lacey J Luense

Martha Z Carletti

Lane K Christenson

Affiliations

Soon will be listed here.

Abstract

Dicer is an RNAse III endonuclease that is essential for the biogenesis of microRNAs and small interfering RNAs. These small RNAs post-transcriptionally regulate mRNA gene expression through several mechanisms to affect key cellular events including proliferation, differentiation and apoptosis. Recently, the role of Dicer function in female reproductive tissues has begun to be elucidated through the use of knockout mouse models. Loss of Dicer within ovarian granulosa cells, luteal tissue, oocyte, oviduct and, potentially, the uterus renders females infertile. This review discusses these early studies and other data describing the current understanding of microRNAs and small interfering RNAs in female reproduction.

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