MicroRNA Biogenesis: There's More Than One Way to Skin a Cat

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2008 Sep 10

PMID 18778799

Citations 53

Authors

Michael Faller

Feng Guo

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNAs) are extensively involved in developmental programming. Some miRNAs are highly conserved, while others are lineage specific. All miRNAs maturate through a series of processing steps. Here we review recent progresses in the studies of early steps in miRNA biogenesis, focusing on animal systems. The miRNA maturation pathways are surprisingly diverse, involving transcription by RNA polymerase II or III, cleavage by the Drosha nuclease or the spliceosome, and sometimes modifications by the adenosine deaminase ADAR. The relationship between the diversity in miRNA biogenesis and the apparently rapid evolution of miRNA genes and functions is discussed.

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