Lacey J Luense
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Explore the profile of Lacey J Luense including associated specialties, affiliations and a list of published articles.
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14
Citations
500
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Recent Articles
1.
Dodd A, Luense L
Front Cell Dev Biol
. 2024 Nov;
12:1476312.
PMID: 39600339
The paternal germline contains a plethora of information that extends beyond DNA. Packaged within the sperm cell is a wealth of epigenetic information, including DNA methylation, small RNAs, and chromatin...
2.
Luense L, Berger S
Cell Host Microbe
. 2021 Mar;
29(3):313-315.
PMID: 33705698
RNA expression of endogenous retroviral elements poses a threat to the genome and to cell function, which may ultimately result in disease. Recently published in Nature, Chelmicki and colleagues (2021)...
3.
Crespo M, Luense L, Arlotto M, Hu J, Dorsey J, Garcia-Oliver E, et al.
Epigenetics Chromatin
. 2020 Sep;
13(1):35.
PMID: 32933557
Background: Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly...
4.
Luense L, Donahue G, Lin-Shiao E, Rangel R, Weller A, Bartolomei M, et al.
Dev Cell
. 2019 Nov;
51(6):745-758.e6.
PMID: 31761669
During mammalian spermatogenesis, germ cell chromatin undergoes dramatic histone acetylation-mediated reorganization, whereby 90%-99% of histones are evicted. Given the potential role of retained histones in fertility and embryonic development, the...
5.
Sen P, Lan Y, Li C, Sidoli S, Donahue G, Dou Z, et al.
Mol Cell
. 2019 Feb;
73(4):684-698.e8.
PMID: 30773298
Accumulation of senescent cells during aging contributes to chronic inflammation and age-related diseases. While senescence is associated with profound alterations of the epigenome, a systematic view of epigenetic factors in...
6.
Schon S, Luense L, Wang X, Bartolomei M, Coutifaris C, Garcia B, et al.
J Assist Reprod Genet
. 2018 Nov;
36(2):267-275.
PMID: 30397898
Purpose: Alternations to the paternal epigenome, specifically the components of sperm chromatin, can lead to infertility in humans and potentially transmit aberrant information to the embryo. One key component of...
7.
Hur S, Freschi A, Ideraabdullah F, Thorvaldsen J, Luense L, Weller A, et al.
Proc Natl Acad Sci U S A
. 2016 Sep;
113(39):10938-43.
PMID: 27621468
Genomic imprinting affects a subset of genes in mammals, such that they are expressed in a monoallelic, parent-of-origin-specific manner. These genes are regulated by imprinting control regions (ICRs), cis-regulatory elements...
8.
Luense L, Wang X, Schon S, Weller A, Lin Shiao E, Bryant J, et al.
Epigenetics Chromatin
. 2016 Jun;
9:24.
PMID: 27330565
Background: During the process of spermatogenesis, male germ cells undergo dramatic chromatin reorganization, whereby most histones are replaced by protamines, as part of the pathway to compact the genome into...
9.
McGinnis L, Luense L, Christenson L
Cold Spring Harb Perspect Med
. 2015 May;
5(9):a022962.
PMID: 25986593
MicroRNAs (miRNAs) are posttranscriptional gene regulatory molecules that show regulated expression within ovarian tissue. Most research investigating miRNAs in the ovary has relied exclusively on in vitro analyses. In this...
10.
Bryant J, Donahue G, Wang X, Meyer-Ficca M, Luense L, Weller A, et al.
Mol Cell Biol
. 2015 Feb;
35(8):1433-48.
PMID: 25691659
During spermiogenesis, the postmeiotic phase of mammalian spermatogenesis, transcription is progressively repressed as nuclei of haploid spermatids are compacted through a dramatic chromatin reorganization involving hyperacetylation and replacement of most...