Ribosomal Peptide Natural Products: Bridging the Ribosomal and Nonribosomal Worlds

Overview

Journal Nat Prod Rep

Publisher Royal Society of Chemistry

Date 2009 Aug 1

PMID 19642421

Citations 115

Authors

John A McIntosh

Mohamed S Donia

Eric W Schmidt

Affiliations

Soon will be listed here.

Abstract

Ribosomally synthesized bacterial natural products rival the nonribosomal peptides in their structural and functional diversity. The last decade has seen substantial progress in the identification and characterization of biosynthetic pathways leading to ribosomal peptide natural products with new and unusual structural motifs. In some of these cases, the motifs are similar to those found in nonribosomal peptides, and many are constructed by convergent or even paralogous enzymes. Here, we summarize the major structural and biosynthetic categories of ribosomally synthesized bacterial natural products and, where applicable, compare them to their homologs from nonribosomal biosynthesis.

Citing Articles

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