Diagnostic Challenges in Celiac Disease and the Role of the Tissue Transglutaminase-neo-epitope

Overview

Journal Clin Rev Allergy Immunol

Specialty Allergy & Immunology

Date 2009 Jul 25

PMID 19629760

Citations 10

Authors

Torsten Matthias

Sascha Pfeiffer

Carlo Selmi

M Eric Gershwin

Affiliations

Soon will be listed here.

Abstract

The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies.

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