Dermatitis Herpetiformis: from the Genetics to the Development of Skin Lesions

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2012 Jul 11

PMID 22778763

Citations 15

Authors

Diletta Bonciani

Alice Verdelli

Veronica Bonciolini

Antonietta DErrico

Emiliano Antiga

Paolo Fabbri

Marzia Caproni

Affiliations

Soon will be listed here.

Abstract

Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions.

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