IVF/ICSI with or Without Preimplantation Genetic Screening for Aneuploidy in Couples Without Genetic Disorders: a Systematic Review and Meta-analysis

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2009 Jul 25

PMID 19629673

Citations 12

Authors

Miguel A Checa

Pablo Alonso-Coello

Ivan Sola

Ana Robles

Ramon Carreras

Juan Balasch

Affiliations

Soon will be listed here.

Abstract

Purpose: To assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders.

Methods: Systematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data.

Results: Ten randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62-0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64-0.91) than standard in vitro fertilization/intracytoplasmic sperm injection.

Conclusions: In women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified.

Citing Articles

Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate?.

Kasaven L, Marcus D, Theodorou E, Jones B, Saso S, Naja R J Assist Reprod Genet. 2023; 40(10):2297-2316.

PMID: 37479946 PMC: 10504192. DOI: 10.1007/s10815-023-02866-0.

A decade of molecular preimplantation genetic diagnosis of 350 blastomeres for beta-thalassemia combined with HLA typing, aneuploidy screening and sex selection in Iran.

Keshvar Y, Sabeghi S, Sharifi Z, Fatemi K, Fouladi P, Younesi Khah S BMC Pregnancy Childbirth. 2022; 22(1):330.

PMID: 35428248 PMC: 9013130. DOI: 10.1186/s12884-022-04660-9.

Analysis of IVF live birth outcomes with and without preimplantation genetic testing for aneuploidy (PGT-A): UK Human Fertilisation and Embryology Authority data collection 2016-2018.

Sanders K, Silvestri G, Gordon T, Griffin D J Assist Reprod Genet. 2021; 38(12):3277-3285.

PMID: 34766235 PMC: 8666405. DOI: 10.1007/s10815-021-02349-0.

PGT-A: who and when? Α systematic review and network meta-analysis of RCTs.

Simopoulou M, Sfakianoudis K, Maziotis E, Tsioulou P, Grigoriadis S, Rapani A J Assist Reprod Genet. 2021; 38(8):1939-1957.

PMID: 34036455 PMC: 8417193. DOI: 10.1007/s10815-021-02227-9.

The Effect of Preimplantation Genetic Screening on Implantation Rate in Women over 35 Years of Age.

Moayeri M, Saeidi H, Modarresi M, Hashemi M Cell J. 2016; 18(1):13-20.

PMID: 27054114 PMC: 4819381. DOI: 10.22074/cellj.2016.3982.

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